Abstract
The formation of peritoneal adhesions represents one of the most common complications after abdominal surgery, and it increases the difficulty of re-operation. Thus, preventing postoperative adhesions is a major problem in the field of surgical medicine. Due to a lack of good predictive animal models and the complexity of adhesion pathogenesis, attempts to prevent or reduce peritoneal adhesions have been largely unsuccessful. As a result, the study of anti-adhesion drugs and materials has become a hot topic for experts and scholars. The processing and development of chitosan and its derivatives as new anti-adhesion materials is highly valued because chitosan is inexpensive, highly biocompatible, and not cytotoxic, making it a promising anti-adhesion material. Here, we review the sources and preparation of chitosan and the progress made toward producing different types of chitosan and its derivatives for preventing adhesion.
Keywords: Chitosan, carboxymethyl chitosan, postoperative peritoneal anti-adhesion.
Mini-Reviews in Medicinal Chemistry
Title:The Processing of Chitosan and Its Derivatives and Their Application for Postoperative Anti-Adhesion
Volume: 15 Issue: 4
Author(s): Lin Zhu, Lin Peng and Yu-Qing Zhang
Affiliation:
Keywords: Chitosan, carboxymethyl chitosan, postoperative peritoneal anti-adhesion.
Abstract: The formation of peritoneal adhesions represents one of the most common complications after abdominal surgery, and it increases the difficulty of re-operation. Thus, preventing postoperative adhesions is a major problem in the field of surgical medicine. Due to a lack of good predictive animal models and the complexity of adhesion pathogenesis, attempts to prevent or reduce peritoneal adhesions have been largely unsuccessful. As a result, the study of anti-adhesion drugs and materials has become a hot topic for experts and scholars. The processing and development of chitosan and its derivatives as new anti-adhesion materials is highly valued because chitosan is inexpensive, highly biocompatible, and not cytotoxic, making it a promising anti-adhesion material. Here, we review the sources and preparation of chitosan and the progress made toward producing different types of chitosan and its derivatives for preventing adhesion.
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Cite this article as:
Zhu Lin, Peng Lin and Zhang Yu-Qing, The Processing of Chitosan and Its Derivatives and Their Application for Postoperative Anti-Adhesion, Mini-Reviews in Medicinal Chemistry 2015; 15 (4) . https://dx.doi.org/10.2174/1389557515666150227110547
DOI https://dx.doi.org/10.2174/1389557515666150227110547 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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