Abstract
Novel macroporous composite hydrogels were synthesized by free radical polymerization of crylic acid (AA), chitosan (CS) and beta-cyclodextrin (β-CD) with N,N-methylenebisacrylamide (MBA) as the cross-linking agent. The structure of the resultant hydrogels was characterized by the Fourier Transform Infrared Spectrum (FT-IR) spectroscopy and Scanning Electron Microscopy (SEM). The thermal stability was also investigated by thermal gravimetric analyzer. The swelling properties were investigated in detail. The results revealed that the prepared hydrogels exhibited high pH sensitivity and well reversible property by undergoing a number of swelling/de-swelling recycles. Nicotinamide was chosen as a model drug to evaluate the controlled drug release behavior. The results indicated that the release rate decreased with the increasing of β-CD content in acidic solution (pH=1.80).
Keywords: CS/β-CD/PAA composite hydrogels, controlled drug delivery, nicotinamide.
Letters in Drug Design & Discovery
Title:Preparation and Characterization of CS/(β-CD)/PAA Composite Hydrogels for Controlled Drug Delivery
Volume: 12 Issue: 6
Author(s): Jie Ren, Xiaoci Yang, Mengqi Yao, Jinfen Gu, Xiaohua Tang and W u Yang
Affiliation:
Keywords: CS/β-CD/PAA composite hydrogels, controlled drug delivery, nicotinamide.
Abstract: Novel macroporous composite hydrogels were synthesized by free radical polymerization of crylic acid (AA), chitosan (CS) and beta-cyclodextrin (β-CD) with N,N-methylenebisacrylamide (MBA) as the cross-linking agent. The structure of the resultant hydrogels was characterized by the Fourier Transform Infrared Spectrum (FT-IR) spectroscopy and Scanning Electron Microscopy (SEM). The thermal stability was also investigated by thermal gravimetric analyzer. The swelling properties were investigated in detail. The results revealed that the prepared hydrogels exhibited high pH sensitivity and well reversible property by undergoing a number of swelling/de-swelling recycles. Nicotinamide was chosen as a model drug to evaluate the controlled drug release behavior. The results indicated that the release rate decreased with the increasing of β-CD content in acidic solution (pH=1.80).
Export Options
About this article
Cite this article as:
Ren Jie, Yang Xiaoci, Yao Mengqi, Gu Jinfen, Tang Xiaohua and Yang u W, Preparation and Characterization of CS/(β-CD)/PAA Composite Hydrogels for Controlled Drug Delivery, Letters in Drug Design & Discovery 2015; 12 (6) . https://dx.doi.org/10.2174/1570180812666150224231250
DOI https://dx.doi.org/10.2174/1570180812666150224231250 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Energetic Metabolic Roles in Pulmonary Arterial Hypertension and Right Ventricular Remodeling
Current Pharmaceutical Design The Role of Nutrition During the COVID-19 Pandemic: What We Know
Endocrine, Metabolic & Immune Disorders - Drug Targets Statins Influence Long Term Restenosis and Cardiovascular Events Following Carotid Endarterectomy
Current Vascular Pharmacology Dental Mesenchymal Stem Cells in Inflamed Microenvironment: Potentials and Challenges for Regeneration
Current Stem Cell Research & Therapy All for Statins and Statins for All; An Update
Current Pharmaceutical Design Benefits of Caloric Restriction on Brain Aging and Related Pathological States: Understanding Mechanisms to Devise Novel Therapies
Current Medicinal Chemistry Recurrent Rearrangements in Prostate Cancer: Causes and Therapeutic Potential
Current Drug Targets Editorial (Thematic Issue: New Trends in Pharmaceutical Nanotechnology)
Current Pharmaceutical Design The Role of AGEs and AGE Inhibitors in Diabetic Cardiovascular Disease
Current Drug Targets Enzyme Inhibition, Kinetic, and Molecular Docking Studies of α-glucosidase
Current Enzyme Inhibition Pharmacological Treatment of Hypoxic-Ischemic Reperfusion Injury of the Newborn Brain in the Clinical Setting: What are the Possibilities in the Near Future?
Current Pediatric Reviews Prognostic Role of Ovarian Reserve Testing
Current Women`s Health Reviews Diabetes Mellitus: A Potential Target for Stem Cell Therapy
Current Stem Cell Research & Therapy Dietary Assumption of Plant Polyphenols and Prevention of Allergy
Current Pharmaceutical Design Recent Developments of C-Aryl Glucoside SGLT2 Inhibitors
Current Medicinal Chemistry Myeloma Cells and Their Interactions With the Bone Marrow Endothelial Cells
Current Immunology Reviews (Discontinued) Food-derived Bioactive Peptides - Opportunities for Designing Future Foods
Current Pharmaceutical Design The Development of Copper Radiopharmaceuticals for Imaging and Therapy
Medicinal Chemistry Pharmacological Profile of SSRIs and SNRIs in the Treatment of Eating Disorders
Current Clinical Pharmacology Ovarian Tissue Vitrification: Modalities, Challenges and Potentials
Current Women`s Health Reviews