Abstract
A simple, efficient, and environmentally benign procedure for the synthesis of 2-amino-4Hchromene ring has been achieved by the three-component reaction of an aromatic aldehyde, malononitrile and diverse enolizable C-H activated compound under ultrasound irradiation using sodium carbonate as a catalyst in aqueous media. Sodium carbonate as a natural salt, being available as an inexpensive catalyst combined with ultrasound method promoted this protocol in comparison to other methods and catalysts.
Keywords: Coumarin, dimedone, green synthesis, naphthol, sodium carbonate.
Combinatorial Chemistry & High Throughput Screening
Title:Ultrasonic Assisted Synthesis of Chromenes Catalyzed by Sodium Carbonate in Aqueous Media
Volume: 18 Issue: 9
Author(s): Maryam Sabbaghan and Pegah Sofalgar
Affiliation:
Keywords: Coumarin, dimedone, green synthesis, naphthol, sodium carbonate.
Abstract: A simple, efficient, and environmentally benign procedure for the synthesis of 2-amino-4Hchromene ring has been achieved by the three-component reaction of an aromatic aldehyde, malononitrile and diverse enolizable C-H activated compound under ultrasound irradiation using sodium carbonate as a catalyst in aqueous media. Sodium carbonate as a natural salt, being available as an inexpensive catalyst combined with ultrasound method promoted this protocol in comparison to other methods and catalysts.
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Cite this article as:
Sabbaghan Maryam and Sofalgar Pegah, Ultrasonic Assisted Synthesis of Chromenes Catalyzed by Sodium Carbonate in Aqueous Media, Combinatorial Chemistry & High Throughput Screening 2015; 18 (9) . https://dx.doi.org/10.2174/1386207318666150224112853
DOI https://dx.doi.org/10.2174/1386207318666150224112853 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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