Abstract
Cilia are microtubule-based organelles, which are ubiquitously expressed in epithelial cells. Cholangiocytes, the epithelial cells lining the biliary tree, have primary cilia extending from their apical plasma membrane into the ductal lumen, where the cilia function as multisensory organelles transducing environmental cues into the cell interior. The decrease or loss of primary cilia has been described in several malignancies, including cholangiocarcinoma, suggesting that the loss of cilia is a common occurrence in neoplastic transformation. In this short review, we describe the expression of cilia in several cancers, explore the mechanisms and consequences of ciliary loss, and discuss the potential use of the primary cilia as therapeutic targets.
Keywords: Primary cilia, cholangiocarcinoma, ciliotherapy, HDAC6, cholangiocyte, bile duct cancer.
Current Drug Targets
Title:Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma
Volume: 18 Issue: 8
Author(s): Sergio A. Gradilone*, Maria J. Lorenzo Pisarello and Nicholas F. LaRusso
Affiliation:
- Cancer Cell Biology and Translational Research. The Hormel Institute, University of Minnesota. 801 16th Avenue NE. Austin, MN 55912,United States
Keywords: Primary cilia, cholangiocarcinoma, ciliotherapy, HDAC6, cholangiocyte, bile duct cancer.
Abstract: Cilia are microtubule-based organelles, which are ubiquitously expressed in epithelial cells. Cholangiocytes, the epithelial cells lining the biliary tree, have primary cilia extending from their apical plasma membrane into the ductal lumen, where the cilia function as multisensory organelles transducing environmental cues into the cell interior. The decrease or loss of primary cilia has been described in several malignancies, including cholangiocarcinoma, suggesting that the loss of cilia is a common occurrence in neoplastic transformation. In this short review, we describe the expression of cilia in several cancers, explore the mechanisms and consequences of ciliary loss, and discuss the potential use of the primary cilia as therapeutic targets.
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Cite this article as:
Gradilone A. Sergio*, Pisarello J. Lorenzo Maria and LaRusso F. Nicholas, Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma, Current Drug Targets 2017; 18 (8) . https://dx.doi.org/10.2174/1389450116666150223162737
DOI https://dx.doi.org/10.2174/1389450116666150223162737 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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