Abstract
Embryonic stem cells (ES cells) hold great potential for regenerative medicine. Grasp of the underlying elaborate machinery is required for clinical application. MicroRNAs serve as important post-transcriptional regulators of various normal and pathological processes. Substantial headway has been made in deciphering miRNAs’ roles in establishment, maintenance and exit from pluripotency in ES cells. Here, we summarize current and ongoing research on microRNAs’ roles of pluripotency maintenance and germ layer specification and possible mechanism to script the cell fate.
Keywords: Embryonic stem cell, germ layer specification, microRNA, pluripotency.
Current Stem Cell Research & Therapy
Title:MicroRNA Regulation of Embryonic Stem Cell Pluripotency and Differentiation
Volume: 10 Issue: 5
Author(s): Xin Zhou, Xuedong Zhou and Liwei Zheng
Affiliation:
Keywords: Embryonic stem cell, germ layer specification, microRNA, pluripotency.
Abstract: Embryonic stem cells (ES cells) hold great potential for regenerative medicine. Grasp of the underlying elaborate machinery is required for clinical application. MicroRNAs serve as important post-transcriptional regulators of various normal and pathological processes. Substantial headway has been made in deciphering miRNAs’ roles in establishment, maintenance and exit from pluripotency in ES cells. Here, we summarize current and ongoing research on microRNAs’ roles of pluripotency maintenance and germ layer specification and possible mechanism to script the cell fate.
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Cite this article as:
Zhou Xin, Zhou Xuedong and Zheng Liwei, MicroRNA Regulation of Embryonic Stem Cell Pluripotency and Differentiation, Current Stem Cell Research & Therapy 2015; 10 (5) . https://dx.doi.org/10.2174/1574888X10666150220155222
DOI https://dx.doi.org/10.2174/1574888X10666150220155222 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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