Abstract
Lipid nanocapsules with their unique composition represent a promising biocompatible drug delivery platform in nanometer range with narrow size distribution. They are highly stable in comparison to other nano-vectors and were found to impart very desirable characteristics to the therapeutic molecule being delivered within. The current review sheds the light on the methods of preparation of lipid nanocapsules, which are simple and easily scalable, in addition to providing examples of post insertion of some compounds for prolonging vascular circulation, protection, and targeting several diseases. In addition, the review discusses the vast in vitro and in vivo applications of lipid nanocapsules when administered via different routes such as oral, parenteral and transdermal routes. Promising use of nanocapsules in treatment of cancer, Alzheimer’s disease, dermatological conditions and other miscellaneous applications are highlighted.
Keywords: Drug targeting, interfacial deposition, nanocapsules, phase inversion temperature method, solvent displacement, surface functionalization.
Current Pharmaceutical Biotechnology
Title:Lipid based Nanocapsules: A Multitude of Biomedical Applications
Volume: 16 Issue: 4
Author(s): Maha Nasr and Sameh Abdel-Hamid
Affiliation:
Keywords: Drug targeting, interfacial deposition, nanocapsules, phase inversion temperature method, solvent displacement, surface functionalization.
Abstract: Lipid nanocapsules with their unique composition represent a promising biocompatible drug delivery platform in nanometer range with narrow size distribution. They are highly stable in comparison to other nano-vectors and were found to impart very desirable characteristics to the therapeutic molecule being delivered within. The current review sheds the light on the methods of preparation of lipid nanocapsules, which are simple and easily scalable, in addition to providing examples of post insertion of some compounds for prolonging vascular circulation, protection, and targeting several diseases. In addition, the review discusses the vast in vitro and in vivo applications of lipid nanocapsules when administered via different routes such as oral, parenteral and transdermal routes. Promising use of nanocapsules in treatment of cancer, Alzheimer’s disease, dermatological conditions and other miscellaneous applications are highlighted.
Export Options
About this article
Cite this article as:
Nasr Maha and Abdel-Hamid Sameh, Lipid based Nanocapsules: A Multitude of Biomedical Applications, Current Pharmaceutical Biotechnology 2015; 16 (4) . https://dx.doi.org/10.2174/138920101604150218103555
DOI https://dx.doi.org/10.2174/138920101604150218103555 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Photodynamic Effects of Vitamin K3 on Cervical Carcinoma Cells Activating Mitochondrial Apoptosis Pathways
Anti-Cancer Agents in Medicinal Chemistry Infection, Stem Cells and Cancer Signals
Current Pharmaceutical Biotechnology Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals
Anti-Cancer Agents in Medicinal Chemistry Cyclin Dependent Kinase 1 Inhibitors: A Review of Recent Progress
Current Medicinal Chemistry Cystic Hygroma with Multiple Benign Bone Lymphangiomas in an Adult Patient: A Rare Entity in the Differential Diagnosis of Multiple Osseous Lesions in Oncology Practice
Current Medical Imaging Pharmacogenetics of Irinotecan Disposition and Toxicity: A Review
Current Clinical Pharmacology A Novel Series of N-aryltriazole and N-acridinyltriazole Hybrids as Potential Anticancer Agents
Current Organic Synthesis Clinical and Pharmacological Aspects of Inflammatory Demyelinating Diseases in Childhood: An Update
Current Neuropharmacology Aptamers: Molecular Tools for Medical Diagnosis
Current Topics in Medicinal Chemistry Influence of Dietary Substances on Intestinal Drug Metabolism and Transport
Current Drug Metabolism Synergistic Effect of α-Solanine and Cisplatin Induces Apoptosis and Enhances Cell Cycle Arrest in Human Hepatocellular Carcinoma Cells
Anti-Cancer Agents in Medicinal Chemistry Editorial (Thematic Issue: Targeting Anti-Cancer Agents and Cancer Treatments)
Anti-Cancer Agents in Medicinal Chemistry Benzocoumarins: Isolation, Synthesis, and Biological Activities
Mini-Reviews in Medicinal Chemistry Expression of HPV 58 Long and Short L1 Capsid Proteins in Primary Mouse Keratinocyte Cultures
Protein & Peptide Letters Development of Metal-Based Drugs and Application in Clinical Treatment
The Natural Products Journal Applications of Computed Tomography, Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy for Planning External Beam Radiotherapy
Current Medical Imaging Recent Advances in Use of Topoisomerase Inhibitors in Combination Cancer Therapy
Current Topics in Medicinal Chemistry Gene Profile Identifies Zinc Transporters Differentially Expressed in Normal Human Organs and Human Pancreatic Cancer
Current Molecular Medicine Quantum Dot-Based Nanoprobes for In Vivo Targeted Imaging
Current Molecular Medicine A Comprehensive Study of Pharmacological Behaviors, Nano-Formulations, and Applications of Rosemary
The Natural Products Journal