Abstract
Certified reference materials (CRMs) play vital roles in method validation and quality assurance of assessment measurements. In this paper, a new CRM for sulfamethoxazole (SMZ) was prepared. Purity determination and uncertainty evaluation methods were developed using mass balance (MB) and differential scanning calorimetry (DSC) methods. Impurities including moisture, volatile components, and inorganic components were accounted for and deducted from 100% using the MB method. Results were consistent between DSC and MB. Certied value of SMZ was 991.6 ± 4.6 mg g-1 (k = 2, P = 0.95). This new CRM can be used to validate analytical methods, improve the accuracy and comparability of measurement data, establish metrological traceability of analytical results, and control the quality of SMZ in relevant pharmaceutical formulations.
Keywords: CRM, purity determination, SMZ, uncertainty evaluation.
Current Analytical Chemistry
Title:Preparation and Certification of Sulfamethoxazole Reference Material by Mass Balance Method and Differential Scanning Calorimetry
Volume: 11 Issue: 3
Author(s): Baoxi Zhang, Ningbo Gong, Dezhi Yang, Guanhua Du, Zhaolin Gao and Yang Lu
Affiliation:
Keywords: CRM, purity determination, SMZ, uncertainty evaluation.
Abstract: Certified reference materials (CRMs) play vital roles in method validation and quality assurance of assessment measurements. In this paper, a new CRM for sulfamethoxazole (SMZ) was prepared. Purity determination and uncertainty evaluation methods were developed using mass balance (MB) and differential scanning calorimetry (DSC) methods. Impurities including moisture, volatile components, and inorganic components were accounted for and deducted from 100% using the MB method. Results were consistent between DSC and MB. Certied value of SMZ was 991.6 ± 4.6 mg g-1 (k = 2, P = 0.95). This new CRM can be used to validate analytical methods, improve the accuracy and comparability of measurement data, establish metrological traceability of analytical results, and control the quality of SMZ in relevant pharmaceutical formulations.
Export Options
About this article
Cite this article as:
Zhang Baoxi, Gong Ningbo, Yang Dezhi, Du Guanhua, Gao Zhaolin and Lu Yang, Preparation and Certification of Sulfamethoxazole Reference Material by Mass Balance Method and Differential Scanning Calorimetry, Current Analytical Chemistry 2015; 11 (3) . https://dx.doi.org/10.2174/1573411011666150213211352
DOI https://dx.doi.org/10.2174/1573411011666150213211352 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
Call for Papers in Thematic Issues
Advancements in biomedicine, corrosion inhibition/monitoring, and lubrication of carbon dots
Carbon dots, a class of carbon-based nanomaterials, have garnered substantial interest in various scientific and engineering fields due to their unique properties, including excellent optical properties, outstanding biocompatibility, easy preparation, good dispersity, ultrasmall size, low toxicity and environmental friendliness. This special issue of Current Analytical Chemistry aims to showcase cutting-edge ...read more
Applications of artificial intelligence in chemical analysis
Artificial intelligence (AI) has demonstrated its versatility in almost all scientific fields, especially analytical chemistry, which is leading the way in the integration of AI. According to Chemical Abstract Services, one of the major disciplines contributing to AI-related publications and patents is analytical chemistry. That?s because techniques such as deep ...read more
Bioanalytical and Biosensor Technologies for Target Molecules
Bioanalytical and biosensor technologies constitute the core of detecting and sensing diverse molecules within living organisms, encompassing proteins, DNA, small molecular metabolites, and beyond. These molecules assume pivotal roles in biological processes, rendering their analysis and sensing indispensable for comprehending biological phenomena and unraveling disease mechanisms. In the current landscape ...read more
Biogeochemistry: global environmental research and management
his issue focuses on the bio-pathways of trace elements (Ni, Co, Cr, Mn, Cd, Pb, Zn and REE) in soil, plant and atmospheric systems. Specific interest in the application of phytotechnologies that utilise hyperaccumulator plants (agro/phytomining). On the basis of understanding the migration and transformation of trace elements in ecosystem, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Longitudinal Functional MRI of Motor and Cognitive Recovery Following Stroke: A Review
Current Medical Imaging Creating Chemical Diversity to Target Protein Kinases
Combinatorial Chemistry & High Throughput Screening The Long Term Biological Consequences of Anorexia Nervosa
Current Nutrition & Food Science Design of Molecules Acting on the Serotonin Receptors
Letters in Drug Design & Discovery New Perspectives on Acetaminophen
Current Cardiology Reviews Understanding the Molecular Mechanism of Sigma-1 Receptors: Towards A Hypothesis that Sigma-1 Receptors are Intracellular Amplifiers for Signal Transduction
Current Medicinal Chemistry Ipsilateral Hippocampal Proteomics Reveals Mitochondrial Antioxidative Stress Impairment in Cortical-Lesioned Chronic Mild Stressed Rats
Current Molecular Medicine Current Status of Tyrosine Hydroxylase in Management of Parkinson’s Disease
CNS & Neurological Disorders - Drug Targets Body Mass Index (BMI) and Cognitive Functions in Later Life
Current Alzheimer Research Cannabinoids and Neuropathic Pain
Mini-Reviews in Medicinal Chemistry In Silico Studies of (2E,5E)-2,5-bis(3-methoxy-4-hydroxy-benzylidene) Cyclopentanone on Proteins AChE and BChE Involved in Alzheimers disease and Ameliorative Effects on Paraquat Induced Oxidative Stress Markers in Drosophila melanogaster
Letters in Drug Design & Discovery Meet Our Editorial Board Member
Anti-Cancer Agents in Medicinal Chemistry Pharmacological Characterisation and Modulation of Neuroplasticity in Humans
Current Neuropharmacology E-MHK-0103 (Mineraxin™): A Novel Nutraceutical with Biological Properties in Menopausal Conditions
Current Drug Metabolism The Inhibitory Effect of Panax Ginseng Extract on Amyloid-like Fibril Formation of Trypsin in Aqueous Ethanol
Protein & Peptide Letters Alzheimers Disease-Associated Neurotoxic Mechanisms and Neuroprotective Strategies
Current Drug Targets - CNS & Neurological Disorders Advanced Echocardiographic Imaging of the Congenitally Malformed Heart
Current Cardiology Reviews Nesfatin-1; Implication in Stress and Stress-associated Anxiety and Depression
Current Pharmaceutical Design Recent Insights into the Biosynthesis and Biological Activities of Natural Xanthones
Current Medicinal Chemistry Commentary (Research Highlights)
CNS & Neurological Disorders - Drug Targets