Abstract
Hepatocellular carcinoma (HCC) is one of the most malignant cancers, with the second highest cancer death rate world-wide, next to lung cancer. The signaling mechanisms in HCC are currently not clear. Notch signaling, which is highly conserved and plays a critical role in many cancers, was found to be aberrantly upregulated in HCC tissues compared to normal liver tissues. Accumulating evidence supports that Notch signaling plays a significantly important role in HCC carcinogenesis. This review discusses the functions of Notch signaling in HCC and its potential therapeutic applications against this cancer.
Keywords: Hepatocellular carcinoma, Notch signaling, oncogene, therapeutics, tumor suppressor.
Anti-Cancer Agents in Medicinal Chemistry
Title:Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?
Volume: 15 Issue: 7
Author(s): Lichun Sun, Guangchun Sun, Yan Yu and David H. Coy
Affiliation:
Keywords: Hepatocellular carcinoma, Notch signaling, oncogene, therapeutics, tumor suppressor.
Abstract: Hepatocellular carcinoma (HCC) is one of the most malignant cancers, with the second highest cancer death rate world-wide, next to lung cancer. The signaling mechanisms in HCC are currently not clear. Notch signaling, which is highly conserved and plays a critical role in many cancers, was found to be aberrantly upregulated in HCC tissues compared to normal liver tissues. Accumulating evidence supports that Notch signaling plays a significantly important role in HCC carcinogenesis. This review discusses the functions of Notch signaling in HCC and its potential therapeutic applications against this cancer.
Export Options
About this article
Cite this article as:
Sun Lichun, Sun Guangchun, Yu Yan and H. Coy David, Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (7) . https://dx.doi.org/10.2174/1871520615666150202102809
DOI https://dx.doi.org/10.2174/1871520615666150202102809 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Deep Tissue Optical and Optoacoustic Molecular Imaging Technologies for Pre-Clinical Research and Drug Discovery
Current Pharmaceutical Biotechnology Aberrant Splicing, Hyaluronan Synthases and Intracellular Hyaluronan as Drivers of Oncogenesis and Potential Drug Targets
Current Cancer Drug Targets Survey of Computational Algorithms for MicroRNA Target Prediction
Current Genomics C-11 Radiochemistry in Cancer Imaging Applications
Current Topics in Medicinal Chemistry Oxidative Stress, Histone Deacetylase and Corticosteroid Resistance in Severe Asthma and COPD
Current Respiratory Medicine Reviews The Need for Calcium Channels in Cell Proliferation
Recent Patents on Anti-Cancer Drug Discovery Rate Limiting Steps of AAV Transduction and Implications for Human Gene Therapy
Current Gene Therapy Aptamers Overview: Selection, Features and Applications
Current Topics in Medicinal Chemistry Feud or Friend? The Role of the miR-17-92 Cluster in Tumorigenesis
Current Genomics Porphyrins as Radiosensitizing Agents for Solid Neoplasms
Current Pharmaceutical Design Insight into Discovery of Next Generation Reversible TMLR Inhibitors Targeting EGFR Activating and Drug Resistant T790M Mutants
Current Cancer Drug Targets Pharmacological Inhibition of the Bcl-2 Family of Apoptosis Regulators as Cancer Therapy
Current Molecular Pharmacology Immunotherapy in Non-Small Cell Lung Cancer: Biological Principles and Future Opportunities
Current Molecular Medicine Synthesis and Evaluation of Biological Activities of a Series of (6-substitutedbenzothiazol-2-yl)acrylamides
Medicinal Chemistry Insulin Secretagogues, Sulfonylurea Receptors and KATP Channels
Current Pharmaceutical Design CXCR4 Inhibitors: Tumor Vasculature and Therapeutic Challenges
Recent Patents on Anti-Cancer Drug Discovery Antibody Fragments as Potential Biopharmaceuticals for Cancer Therapy: Success and Limitations
Current Medicinal Chemistry Radiolabelled Regulatory Peptides for Imaging and Therapy
Anti-Cancer Agents in Medicinal Chemistry Review of Chemoradiotherapy for High-Risk Prostate Cancer
Reviews on Recent Clinical Trials Armed Oncolytic Adenoviruses and Polymer-shielded Nanocomplex for Systemic Delivery
Current Cancer Therapy Reviews