Cardioprotection by Targeting the Pool of Resident and Extracardiac Progenitors

Title:Cardioprotection by Targeting the Pool of Resident and Extracardiac Progenitors

Volume: 16 Issue: 8

Author(s): Monia Savi, Federico Quaini, Antonella De Angelis, Francesco Rossi, Eugenio Quaini, Fancesca Re, Costanza Annamaria Lagrasta, Pietro Rossetti, Federica Galaverna, Francesca Ferraro, Konrad Urbanek, Lucia Prezioso, Andrea Gervasi, Bruno Lorusso, Stefano Cavalli, Angela Falco, Denise Madeddu, Gallia Graiani and Caterina Frati

Affiliation:

Keywords: Cardiac progenitors, cardioprotection, cardiotoxiciy, ischemic cardiomyopathy, regenerative medicine, stem cells.

Abstract: The adult heart has the capacity to generate new myocytes that are markedly enhanced in acute and chronic heart failure of ischemic and non-ischemic origin. In addition, a pool of blood trafficking progenitor cells able to sense myocardial damage may home to the sites of injury participating to cardiac repair. This new view of myocardial biology leads to an expanding long-term research and therapeutic goals for cardioprotection. A fundamental concept to be analyzed is whether cardiac diseases are influenced by changes in the properties of tissue specific and circulating progenitors. Loss of self-renewal capacity, impaired growth or increased susceptibility to death may lead to a reduction of progenitors and leave myocardial damage unrepaired. Cardiac progenitors generate all myocardial cell lineages, thus impairment in their growth is expected to be critically involved in the structural and functional modifications of the heart. The fact that, in addition to well known effects of anthracyclines, also new drugs that target molecular pathways implicated in cell death and growth can be cardiotoxic further supports our hypothesis. Understanding the role of resident and extracardiac progenitors in the pathogenesis of cardiomyopathies of different etiology will provide not only a better comprehension of cardiac homeostasis but will also open new avenues for therapeutic interventions. The progress toward effective myocardial regeneration based on exploiting the self-renewal potential of the myocardium and the systemic pool of cardiogenic cells should advance the likelihood of efficient cardioprotection and restoration of cardiac function.

Cite this article as:

Savi Monia, Quaini Federico, Angelis De Antonella, Rossi Francesco, Quaini Eugenio, Re Fancesca, Lagrasta Annamaria Costanza, Rossetti Pietro, Galaverna Federica, Ferraro Francesca, Urbanek Konrad, Prezioso Lucia, Gervasi Andrea, Lorusso Bruno, Cavalli Stefano, Falco Angela, Madeddu Denise, Graiani Gallia and Frati Caterina, Cardioprotection by Targeting the Pool of Resident and Extracardiac Progenitors, Current Drug Targets 2015; 16 (8) . https://dx.doi.org/10.2174/1389450116666150126105002