Abstract
Neopeltolide, isolated in 2007, with its novel structural features and potent anti-cancer cell proliferation activity, has attracted a tremendous amount of synthetic efforts. This review briefly and chronologically summarizes each synthesis with the main focus on the strategies and methodologies for the construction of its cistetrahydropyran- containing macrolactone core.
Keywords: Anticancer, carbonylation, macrolactone, neopeltolide, palladium, tetrahydropyran.
Current Organic Chemistry
Title:Strategies and Methods for the Synthesis of Anticancer Natural Product Neopeltolide and its Analogs
Volume: 19 Issue: 10
Author(s): Yu Bai and Mingji Dai
Affiliation:
Keywords: Anticancer, carbonylation, macrolactone, neopeltolide, palladium, tetrahydropyran.
Abstract: Neopeltolide, isolated in 2007, with its novel structural features and potent anti-cancer cell proliferation activity, has attracted a tremendous amount of synthetic efforts. This review briefly and chronologically summarizes each synthesis with the main focus on the strategies and methodologies for the construction of its cistetrahydropyran- containing macrolactone core.
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Cite this article as:
Bai Yu and Dai Mingji, Strategies and Methods for the Synthesis of Anticancer Natural Product Neopeltolide and its Analogs, Current Organic Chemistry 2015; 19 (10) . https://dx.doi.org/10.2174/1385272819666150119225149
DOI https://dx.doi.org/10.2174/1385272819666150119225149 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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