Abstract
A series of compounds having the pyranopyrazole pharmacophore were synthesised by the traditional method and then by an unreported rapid four-component microwave assisted method. The microwave strategy required substantially shorter reaction times as compared to the traditional method. The prepared molecules were tested in-vitro for their cytotoxic activity against the Hep3B cancer cell lines. The activity results were subsequently rationalized for a quick structure-activity relationship leading to the conclusion that the presence of certain heteroatom substituents at a 3-position of the pharmacophore may be crucial for anticancer potency.
Keywords: Anticancer, green chemistry, heterocycles, microwave assisted synthesis, pyranopyrazole.
Current Microwave Chemistry
Title:Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents
Volume: 3 Issue: 1
Author(s): Ashok Sharma, Rajdeep Chowdhury, Subhra Dash, Badvel Pallavi and Paritosh Shukla
Affiliation:
Keywords: Anticancer, green chemistry, heterocycles, microwave assisted synthesis, pyranopyrazole.
Abstract: A series of compounds having the pyranopyrazole pharmacophore were synthesised by the traditional method and then by an unreported rapid four-component microwave assisted method. The microwave strategy required substantially shorter reaction times as compared to the traditional method. The prepared molecules were tested in-vitro for their cytotoxic activity against the Hep3B cancer cell lines. The activity results were subsequently rationalized for a quick structure-activity relationship leading to the conclusion that the presence of certain heteroatom substituents at a 3-position of the pharmacophore may be crucial for anticancer potency.
Export Options
About this article
Cite this article as:
Sharma Ashok, Chowdhury Rajdeep, Dash Subhra, Pallavi Badvel and Shukla Paritosh, Fast Microwave Assisted Synthesis of Pyranopyrazole Derivatives as New Anticancer Agents, Current Microwave Chemistry 2016; 3 (1) . https://dx.doi.org/10.2174/2213335602666150116233238
DOI https://dx.doi.org/10.2174/2213335602666150116233238 |
Print ISSN 2213-3356 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3364 |
Call for Papers in Thematic Issues
Microwave Technology: Advancements and Applications in Chemistry, Environment and Food Science
Microwave technology has emerged as a transformative tool in various fields, offering unique opportunities for rapid, efficient, and clean processes. This thematic issue aims to encapsulate the latest research, innovative strategies, and progressive methodologies concerning the application of microwave technology in three main areas: Chemistry: Highlighting the advancements in microwave-assisted ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Synthesis and Pharmacological Activities of Oxadiazole and Pyrimidine Bearing Thiocoumarin Derivatives
Current Microwave Chemistry Current Strategies in TB Immunotherapy
Current Molecular Medicine Recent Developments in Drug Design of NO-donor Hybrid Compounds
Mini-Reviews in Medicinal Chemistry Reverse Pharmacognosy: Another Way to Harness the Generosity of Nature
Current Pharmaceutical Design The Role of Vitamin D in Atherosclerosis Inflammation Revisited: More a Bystander than a Player?
Current Vascular Pharmacology MenA Is a Promising Drug Target for Developing Novel Lead Molecules to Combat Mycobacterium tuberculosis
Medicinal Chemistry Graphical Abstracts
Letters in Drug Design & Discovery Methods for Docking Small Molecules to Macromolecules: A User’s Perspective. 2. Applications
Current Pharmaceutical Design BMI1 Regulation of Self-Renewal and Multipotency in Human Mesenchymal Stem Cells
Current Stem Cell Research & Therapy Identification of Active Phytochemical from Traditional Herbal Knowledge-base Targeting Pantothenate Synthetase for Anti-tuberculosis Therapy
Letters in Drug Design & Discovery The Beneficial Effects of QIAPI 1<sup>®</sup> against Pentavalent Arsenic-Induced Lung Toxicity: A Hypothetical Model for SARS CoV2-I nduced Lung Toxicity
Current Pharmaceutical Biotechnology Neuro-psychopharmacogenetics and Neurological Antecedents of Posttraumatic Stress Disorder: Unlocking the Mysteries of Resilience and Vulnerability
Current Neuropharmacology Phosphoserine Aminotransferase has Conserved Active Site from Microbes to Higher Eukaryotes with Minor Deviations
Protein & Peptide Letters Impairment of T Cell Immunity by the Respiratory Syncytial Virus: Targeting Virulence Mechanisms for Therapy and Prophylaxis
Current Medicinal Chemistry Ibalizumab-Human CD4 Receptor Interaction: Computational Alanine Scanning Molecular Dynamics Studies
Current Computer-Aided Drug Design Anti-Inflammatory Properties of Drugs from saffron crocus
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Fullerenes for Cancer Diagnosis and Therapy: Preparation, Biological and Clinical Perspectives
Current Drug Metabolism Peptide Biomarkers: Exploring the Diagnostic Aspect
Current Protein & Peptide Science Mycobacterium tuberculosis Treatment Modalities and Recent Insights
Current Drug Delivery An Overwiev of ORF Virus Infection in Humans and Animals
Recent Patents on Anti-Infective Drug Discovery