Abstract
From last few years research work on heterocyclic compound and their derivatives has been increasing. Benzothiazole molecule has a heterocyclic structure, basic in nature with wide variety of active sites. As a small molecule, it contains electronegative atoms due to which it is feasible for other moieties to form conjugates. Referring to the bioorganic and medicinal chemistry, the moiety has potential to give active pharmacophores to develop new therapeutically important compounds. Benzothiazole derivatives were found to exhibit efficacy against some very serious diseases like cancer, neurodegeneration, neuropathic pain, infectious diseases, epilepsy etc. In the present review, antiepileptic profile of benzothiazole derivatives is emphasized.
Keywords: Anticonvulsant, antiepileptic, benzothiazole, MES, neurotoxicity, PTZ.
Central Nervous System Agents in Medicinal Chemistry
Title:Anticonvulsant and Neurological Profile of Benzothiazoles: A Mini-Review
Volume: 15 Issue: 1
Author(s): Jagbir Gagoria, Prabhakar Kumar Verma and Anurag Khatkar
Affiliation:
Keywords: Anticonvulsant, antiepileptic, benzothiazole, MES, neurotoxicity, PTZ.
Abstract: From last few years research work on heterocyclic compound and their derivatives has been increasing. Benzothiazole molecule has a heterocyclic structure, basic in nature with wide variety of active sites. As a small molecule, it contains electronegative atoms due to which it is feasible for other moieties to form conjugates. Referring to the bioorganic and medicinal chemistry, the moiety has potential to give active pharmacophores to develop new therapeutically important compounds. Benzothiazole derivatives were found to exhibit efficacy against some very serious diseases like cancer, neurodegeneration, neuropathic pain, infectious diseases, epilepsy etc. In the present review, antiepileptic profile of benzothiazole derivatives is emphasized.
Export Options
About this article
Cite this article as:
Gagoria Jagbir, Verma Kumar Prabhakar and Khatkar Anurag, Anticonvulsant and Neurological Profile of Benzothiazoles: A Mini-Review, Central Nervous System Agents in Medicinal Chemistry 2015; 15 (1) . https://dx.doi.org/10.2174/1871524915666150112094206
DOI https://dx.doi.org/10.2174/1871524915666150112094206 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Lexical Characterisation of Bio-Ontologies by the Inspection of Regularities in Labels
Current Bioinformatics Contrasting Roles of the Galectin-3 in the Schizophrenia Onset, Clinical Presentation, and Somatic Comorbidity
Current Topics in Medicinal Chemistry Editorial [Is Drug Safety Dangerous?]
Current Drug Safety Delineating Somatostatins Neuronal Actions
Current Drug Targets - CNS & Neurological Disorders Zebrafish as a Platform for Studies on Seizures and Epilepsy
Current Psychopharmacology Neural Networks in Generalized Epilepsy and Novel Antiepileptic Drugs
Current Pharmaceutical Design Targeting Oxidative Stress Component in the Therapeutics of Epilepsy
Current Topics in Medicinal Chemistry Combined Virtual Screening Strategies
Current Computer-Aided Drug Design Vasculogenic and Angiogenic Pathways in Moyamoya Disease
Current Medicinal Chemistry Barbiturates: A Review of Synthesis and Antimicrobial Research Progress
Current Organic Synthesis Calixarene: A Versatile Material for Drug Design and Applications
Current Pharmaceutical Design Novel 3-{4-[2-Amino-4-(Substitutedphenyl)-2H-[1, 3] Oxazin/Thiazin-6-Yl} -2-Phenyl-3H-Quinazolin-4-One Derivatives as Enhancer of GABA Mediated Inhibition: Synthesis, Molecular Modeling and Pharmacological Studies
Letters in Drug Design & Discovery Infantile Epileptic Encephalopathy with Hypsarrhythmia (Infantile Spasms/West Syndrome) and Immunity
Central Nervous System Agents in Medicinal Chemistry Analyses of Associations Between Reactive Oxygen Metabolites and Antioxidant Capacity and Related Factors Among Healthy Adolescents
Current Aging Science MicroRNAs as Biomarkers for Birth Defects
MicroRNA From Axonal Transport to Mitochondrial Trafficking: What Can We Learn from Manganese-Enhanced MRI Studies in Mouse Models of Alzheimers Disease?
Current Medical Imaging A Role of GABA Analogues in the Treatment of Neurological Diseases
Current Medicinal Chemistry Lamotrigine as an Effective Treatment for Behavioral Disorders
Letters in Drug Design & Discovery TRPC Channels and their Implications for Neurological Diseases
CNS & Neurological Disorders - Drug Targets Single Amino Acid Repeats Connect Viruses to Neurodegeneration
Current Drug Discovery Technologies