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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

3,4-DHQLO and Triazole and Its Related Analogues with Anticonvulsant Effects

Author(s): Li-Ping Guan and Zhe-Shan Quan

Volume 16, Issue 4, 2016

Page: [323 - 342] Pages: 20

DOI: 10.2174/1389557515666150101100909

Price: $65

Abstract

The derivatives of quinolinone and triazole exhibit antitumor, antiplatelet, antidepressant, and anticonvulsant properties in diverse experimental systems. In the past decades, we have developed increasingly potent anticonvulsant agents by the structural modification of compounds derived from 3,4-DHQLO, triazole, and their analogs. Herein, we report the design and synthesis of a new series of 3,4-DHQLO and triazole and their derivatives; their anticonvulsant activity was evaluated. Moreover, we also reviewed the anticonvulsant activity of 3,4-DHQLO and triazole and their derivatives and new approaches.

Keywords: Anticonvulsant activity, 3, 4-DHQLO, Synthesis, Structure-activity relationship, Triazole.

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