Abstract
The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.
Keywords: Bioreactors, Biosensors, Delivery, Drug, Encapsulation, Sol-gel, Tissue engineering.
Current Topics in Medicinal Chemistry
Title:Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications
Volume: 15 Issue: 3
Author(s): Xiaolin Wang, Nada Ben Ahmed, Gisela S. Alvarez, Maria V. Tuttolomondo, Christophe Helary, Martin F. Desimone and Thibaud Coradin
Affiliation:
Keywords: Bioreactors, Biosensors, Delivery, Drug, Encapsulation, Sol-gel, Tissue engineering.
Abstract: The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.
Export Options
About this article
Cite this article as:
Wang Xiaolin, Ahmed Ben Nada, Alvarez S. Gisela, Tuttolomondo V. Maria, Helary Christophe, Desimone F. Martin and Coradin Thibaud, Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications, Current Topics in Medicinal Chemistry 2015; 15 (3) . https://dx.doi.org/10.2174/1568026614666141229112734
DOI https://dx.doi.org/10.2174/1568026614666141229112734 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Endothelial Chemokines in Autoimmune Disease
Current Pharmaceutical Design Evidence of Lifestyle Modification in the Management of Hypercholesterolemia
Current Cardiology Reviews Desmopressin 30 Years in Clinical Use: A Safety Review
Current Drug Safety Overcoming Barriers to Evidence-Based Diabetes Care
Current Diabetes Reviews The Role for Oxidative Stress in Aberrant DNA Methylation in Alzheimer’s Disease
Current Alzheimer Research Anti-Infectious Activity in the Cistaceae Family in the Iberian Peninsula
Mini-Reviews in Medicinal Chemistry Selective Glucocorticoid Receptor Ligands
Medicinal Chemistry The Application of Angiotensin Converting Enzyme Inhibitors in Heart Surgery
Letters in Drug Design & Discovery Estrogen: Roles in Spermatogenesis
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Impact of DMPEI on Biofilm Adhesion on Latex Urinary Catheter
Recent Patents on Biotechnology Molecular Determinants of the Cardiometabolic Phenotype
Endocrine, Metabolic & Immune Disorders - Drug Targets The Multifactorial Nature of Alzheimer's Disease for Developing Potential Therapeutics
Current Topics in Medicinal Chemistry Hypertension, Prehypertension and Blood Pressure Related Diseases
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Sequential Comorbidity of Anxiety and Depression in Youth: Present Knowledge and Future Directions
Current Psychiatry Reviews Therapeutic Strategies in the Treatment of Diabetic Nephropathy - a Translational Medicine Approach
Current Medicinal Chemistry Current Concepts for Optimizing the Therapeutic Index of Glucocorticoid Receptor Ligands for Oral and Inhalative Use: Basic Considerations and Clinical Reality
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents CycloSal-Pronucleotides of Brivudine Monophosphate - Highly Active Antiviral Agents
Current Medicinal Chemistry - Anti-Infective Agents Inhaled Dry Powder Formulations for Treating Tuberculosis
Current Drug Delivery Development of DNA Methyltransferase Inhibitors for the Treatment of Neoplastic Diseases
Current Medicinal Chemistry Cannabinoids, Opioids and MDMA: Neuropsychological Interactions Related to Addiction
Current Drug Targets