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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents

Author(s): Concepcion Alonso, Maria Fuertes, Maria Gonzalez, Alicia Rodriguez-Gascon, Gloria Rubiales and Francisco Palacios

Volume 14, Issue 23, 2014

Page: [2722 - 2728] Pages: 7

DOI: 10.2174/1568026614666141215152441

Price: $65

Abstract

The synthesis of a variety of phenyl- and indeno-1,5-naphthyridine derivatives as new substrates with anticancer activity is described. Several of the prepared products were addressed to in vitro anticancer screening which indicated that some of them exhibited inhibitory effect of Top1 and antiproliferative activity against human colon cancer cells (COLO 205).

Keywords: Camptothecin, cytotoxicity, heterocycles, inhibitory activity, naphthyridines, topoisomerase I.

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