Abstract
Vaccines are primarily employed for triggering the acquired immune response of the body to combat against diverse pathogenic organisms. Conventional approaches for vaccine delivery possess multiple challenges for effective delivery owing to lack of potential for targeting ability to a particular antigen and protection of antigens from physiological environments of body. In the past a few decades, nanocolloidal carriers have gained higher attention in vaccine delivery due to advantages of targeting ability, reduced immunogenicity and significant augmentation in immune response. Instances of colloidal carriers employed for vaccine delivery include liposomes, niosomes, microspheres, proteosomes, virosomes and virus like particles, reconstituted influenza viruses, immunostimulating complexes, antigen cochleates, etc. Further, surface engineering of these carriers with ligands, functional moieties and monoclonal antibodies has yielded enhanced immune recognition potential to the vaccine antigens for eliciting immune response by promoting differentiation of the antigen specific memory T-cells. In a nutshell, the present review provides an updated and exhaustive account on the recent advancements in various colloidal delivery systems employed for vaccine delivery outlining their potential applications, mechanism of augmenting the immune response and instances of the products existing in market in an explicit manner.
Keywords: Nanocarriers, vaccines, liposomes, IRIVs, niosomes, immune response.
Current Drug Therapy
Title:Novel Nanocolloidal Carriers for Noninvasive Vaccine Delivery
Volume: 9 Issue: 3
Author(s): Sarwar Beg, Mahfoozur Rahman, Suryakanta Swain and Syed Sarim Imam
Affiliation:
Keywords: Nanocarriers, vaccines, liposomes, IRIVs, niosomes, immune response.
Abstract: Vaccines are primarily employed for triggering the acquired immune response of the body to combat against diverse pathogenic organisms. Conventional approaches for vaccine delivery possess multiple challenges for effective delivery owing to lack of potential for targeting ability to a particular antigen and protection of antigens from physiological environments of body. In the past a few decades, nanocolloidal carriers have gained higher attention in vaccine delivery due to advantages of targeting ability, reduced immunogenicity and significant augmentation in immune response. Instances of colloidal carriers employed for vaccine delivery include liposomes, niosomes, microspheres, proteosomes, virosomes and virus like particles, reconstituted influenza viruses, immunostimulating complexes, antigen cochleates, etc. Further, surface engineering of these carriers with ligands, functional moieties and monoclonal antibodies has yielded enhanced immune recognition potential to the vaccine antigens for eliciting immune response by promoting differentiation of the antigen specific memory T-cells. In a nutshell, the present review provides an updated and exhaustive account on the recent advancements in various colloidal delivery systems employed for vaccine delivery outlining their potential applications, mechanism of augmenting the immune response and instances of the products existing in market in an explicit manner.
Export Options
About this article
Cite this article as:
Beg Sarwar, Rahman Mahfoozur, Swain Suryakanta and Imam Sarim Syed, Novel Nanocolloidal Carriers for Noninvasive Vaccine Delivery, Current Drug Therapy 2014; 9 (3) . https://dx.doi.org/10.2174/1574885509666141202233804
DOI https://dx.doi.org/10.2174/1574885509666141202233804 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
Call for Papers in Thematic Issues
Novel Therapeutic Approaches and Biomarkers for Chronic Kidney Disease (CKD)
The thematic issue on "Novel Therapeutic Approaches and Biomarkers for CKD" aims to provide a comprehensive exploration of cutting-edge strategies for the management of chronic kidney disease (CKD). This issue will delve into emerging therapeutic targets, focusing on critical aspects such as podocyte injury, endothelial dysfunction, and tubulointerstitial fibrosis, which ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Antiviral Effects of Saffron and its Major Ingredients
Current Drug Delivery A Review on Structures and Functions of Bcl-2 Family Proteins from Homo sapiens
Protein & Peptide Letters Coumarins as Antioxidants
Current Medicinal Chemistry Influence of New Synthetic Xanthones on the Proliferation and Migration Potential of Cancer Cell Lines In Vitro
Anti-Cancer Agents in Medicinal Chemistry Biological Function and Medicinal Research Significance of G-Quadruplex Interactive Proteins
Current Topics in Medicinal Chemistry Methionine Aminopeptidases as Potential Targets for Treatment of Gastrointestinal Cancers and other Tumors
Current Drug Targets Recent Progress in Stimuli-Responsive Intelligent Nano Scale Drug Delivery Systems: A Special Focus Towards pH-Sensitive Systems
Current Drug Targets VDAC1 as a Player in Mitochondria-Mediated Apoptosis and Target for Modulating Apoptosis
Current Medicinal Chemistry Biological Properties of Yeast-based Mannoprotein for Prospective Biomedical Applications
Combinatorial Chemistry & High Throughput Screening Polarized Angular Dependent Light Scattering Properties of Bare and PEGylated Gold Nanoshells
Current Nanoscience Three-Dimensional Intravenous Digital Subtraction Angiography Using Flat Panel Detector System in Vascular Mapping of the External Carotid Artery: A Comparison with 3-Dimensional Computed Tomography Angiography
Current Medical Imaging Acute Toxicological and Histopathological Elucidation of <i>Rheum emodi</i> Rhizome Extract to Demonstrate Antidiabetic Activity in Alloxan-induced Diabetic Rats
Current Bioactive Compounds Disulfiram, and Disulfiram Derivatives as Novel Potential Anticancer Drugs Targeting the Ubiquitin Proteasome System in Both Preclinical and Clinical Studies
Current Cancer Drug Targets Nanoplatforms for Promoting Osteogenesis in Ovariectomy-Induced Osteoporosis in the Experimental Model
Current Nanomedicine Mechanisms and Treatment of Neuropathic Pain
Central Nervous System Agents in Medicinal Chemistry Parathyroid Hormone Determination in Ultrasound-Guided Fine Needle Aspirates Allows the Differentiation between Thyroid and Parathyroid Lesions: Our Experience and Review of the Literature
Endocrine, Metabolic & Immune Disorders - Drug Targets Polyphenols: Potential Future Arsenals in the Treatment of Diabetes
Current Pharmaceutical Design Anticancer Activity and DNA Binding of 4-Alkylenediamines Modified Naphthalimide Derivatives
Letters in Drug Design & Discovery Porphyrins in Photodynamic Therapy - A Search for Ideal Photosensitizers
Current Medicinal Chemistry - Anti-Cancer Agents Iron Chelating Strategies in Systemic Metal Overload, Neurodegeneration and Cancer
Current Medicinal Chemistry