Total Synthesis of Diversified 1,2-disubstituted Benzimidazoles with Green Approach at Room Temperature

Title:Total Synthesis of Diversified 1,2-disubstituted Benzimidazoles with Green Approach at Room Temperature

Volume: 11 Issue: 10

Author(s): Yeong Keng Yoon, Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Lim Wan Leng and Oo Chuan Wei

Affiliation:

Keywords: Benzimidazoles, cycloaddition, green chemistry, reduction, sodium bisulfite, total synthesis.

Abstract: A green and facile method to synthesize diversified 1,2-disubstituted benzimidazoles has been developed. The total synthesis was performed at room temperature utilizing water and ethanol as solvents. As aqueous media and ethanol have low toxicity and are easily recyclable, the method presented is very suitable for scale-up production. Furthermore, products were obtained in high yield and easily isolated making this method very practical and attractive.

Cite this article as:

Yoon Keng Yeong, Ali Ashraf Mohamed, Wei Chee Ang, Choon Soo Tan, Leng Wan Lim and Wei Chuan Oo, Total Synthesis of Diversified 1,2-disubstituted Benzimidazoles with Green Approach at Room Temperature, Letters in Organic Chemistry 2014; 11 (10) . https://dx.doi.org/10.2174/157017861110141117150010