Abstract
The study introduced a new therapeutic agent, fucoidan, which can offer potential medical treatments including anti-inflammatory and anti-coagulant activities, as well as anti-proliferative effects on cancer cells. Fucoidan was included in sustained release formulations expected for an effective plasma drug concentration for approximately 24 h. The matrices based on the two polymers hydroxypropyl methycellulose (HPMC) and polyethylene oxide (PEO) were prepared with various ratios between the polymers and fucoidan. The dissolution profiles of various matrix tablets performed in enzyme- free simulated intestinal fluid (pH 6.8) for 24 h indicated a higher potential of PEO-based matrix tablets in sustaining release of fucoidan. The swelling and erosion of the tablets were also characterized to elucidate the difference among those dissolution profiles.
Keywords: Fucoidan, hydroxypropyl methycellulose, polyethylene oxide, sustained drug release.
Current Drug Delivery
Title:Design of Sustained Release Tablet Containing Fucoidan
Volume: 12 Issue: 2
Author(s): Thao Truong-Dinh Tran, Dai Kieu-Phuong Ngo, Toi Van Vo and Phuong Ha-Lien Tran
Affiliation:
Keywords: Fucoidan, hydroxypropyl methycellulose, polyethylene oxide, sustained drug release.
Abstract: The study introduced a new therapeutic agent, fucoidan, which can offer potential medical treatments including anti-inflammatory and anti-coagulant activities, as well as anti-proliferative effects on cancer cells. Fucoidan was included in sustained release formulations expected for an effective plasma drug concentration for approximately 24 h. The matrices based on the two polymers hydroxypropyl methycellulose (HPMC) and polyethylene oxide (PEO) were prepared with various ratios between the polymers and fucoidan. The dissolution profiles of various matrix tablets performed in enzyme- free simulated intestinal fluid (pH 6.8) for 24 h indicated a higher potential of PEO-based matrix tablets in sustaining release of fucoidan. The swelling and erosion of the tablets were also characterized to elucidate the difference among those dissolution profiles.
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Cite this article as:
Truong-Dinh Tran Thao, Kieu-Phuong Ngo Dai, Vo Toi Van and Ha-Lien Tran Phuong, Design of Sustained Release Tablet Containing Fucoidan, Current Drug Delivery 2015; 12 (2) . https://dx.doi.org/10.2174/1567201811666141109210850
DOI https://dx.doi.org/10.2174/1567201811666141109210850 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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