Abstract
Nanoparticles have shown great promise for improving the efficacy of nucleic acid drugs that lack permeability and bioavailability needed for reaching their intracellular site of action. The pharmacokinetics of the nucleic acid nanomedicines contributes greatly to their pharmacodynamic and toxicity characteristics. The pharmacokinetics of nanomedicines is determined by their physiochemical properties, such as particle size, shape, surface charge, and surface modifications. This review presented the pharmacokinetic and pharmacodynamic perspectives of nucleic acid nanomedicines. The cellular trafficking of the nucleic acid nanomedicines after cellular uptake is also discussed. In addition, the review puts forward potential strategies for circumventing biological barriers to delivering and releasing nucleic acid drugs into their intracellular site of action, and perspectives in this rapidly evolving field.
Keywords: Antisense oligonucleotide, gene therapy, intracellular trafficking, microRNA, nanomedicine, pharmacodynamic, pharmacokinetic, plasmid DNA, small interfering RNA.
Current Pharmaceutical Biotechnology
Title:Nanomedicine based on Nucleic Acids: Pharmacokinetic and Pharmacodynamic Perspectives
Volume: 15 Issue: 9
Author(s): Chenguang Zhou, Zhaogang Yang and Lesheng Teng
Affiliation:
Keywords: Antisense oligonucleotide, gene therapy, intracellular trafficking, microRNA, nanomedicine, pharmacodynamic, pharmacokinetic, plasmid DNA, small interfering RNA.
Abstract: Nanoparticles have shown great promise for improving the efficacy of nucleic acid drugs that lack permeability and bioavailability needed for reaching their intracellular site of action. The pharmacokinetics of the nucleic acid nanomedicines contributes greatly to their pharmacodynamic and toxicity characteristics. The pharmacokinetics of nanomedicines is determined by their physiochemical properties, such as particle size, shape, surface charge, and surface modifications. This review presented the pharmacokinetic and pharmacodynamic perspectives of nucleic acid nanomedicines. The cellular trafficking of the nucleic acid nanomedicines after cellular uptake is also discussed. In addition, the review puts forward potential strategies for circumventing biological barriers to delivering and releasing nucleic acid drugs into their intracellular site of action, and perspectives in this rapidly evolving field.
Export Options
About this article
Cite this article as:
Zhou Chenguang, Yang Zhaogang and Teng Lesheng, Nanomedicine based on Nucleic Acids: Pharmacokinetic and Pharmacodynamic Perspectives, Current Pharmaceutical Biotechnology 2014; 15 (9) . https://dx.doi.org/10.2174/1389201015666141020155620
DOI https://dx.doi.org/10.2174/1389201015666141020155620 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Evaluation of the Effects of 1,25 Vitamin D3 on Regulatory T Cells and T Helper 17 Cells in Vitamin D-deficient Women with Unexplained Recurrent Pregnancy Loss
Current Molecular Pharmacology RNA Interference in Cancer: Targeting the Anti-Apoptotic Protein c-FLIP for Drug Discovery
Mini-Reviews in Medicinal Chemistry The Intensity Modulated Multiple Arc (IMMA) Technique: Forward & Inverse Planned Procedures to Deliver Hypo- Fractionated IMAT Treatments
Current Radiopharmaceuticals Energy Balance and Carcinogenesis: Underlying Pathways and Targets for Intervention
Current Cancer Drug Targets Interleukin-6: A Critical Cytokine in Cancer Multidrug Resistance
Current Pharmaceutical Design Regulation of Mesenchymal Phenotype by MicroRNAs in Cancer
Current Cancer Drug Targets The Role of NF-κB Inhibitors in Cell Response to Radiation
Current Medicinal Chemistry The Battle of the Sexes for Stroke Therapy: Female- Versus Male-Derived Stem Cells
CNS & Neurological Disorders - Drug Targets Biomarkers for Cancers in Women: Present Status and Future Perspectives
Current Women`s Health Reviews Endometrial Cancer as a Familial Tumor: Pathology and Molecular Carcinogenesis (Review)
Current Genomics Understanding the Monoclonal Antibody Involvement in Targeting the Activation of Tumor Suppressor Genes
Current Topics in Medicinal Chemistry Targetin g Human Tel omerase by Antisens e Oligonucleotides and Ribozymes
Current Medicinal Chemistry - Anti-Cancer Agents Crosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pieces of an Incomplete Puzzle for Lung Cancer Therapy
Current Cancer Drug Targets Ruthenium Antimetastatic Agents
Current Topics in Medicinal Chemistry Molecular Chaperone Hsp90 as a Target for Oxidant-Based Anticancer Therapies
Current Medicinal Chemistry Targeting Heat Shock Proteins 70/90 and Proteasome for Cancer Therapy
Current Medicinal Chemistry Different 6-Aryl-Fulvenes Exert Anti-proliferative effects on Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Deregulation of the Akt Pathway in Human Cancer
Current Cancer Drug Targets The Antiprogestogen Mifepristone: A Review
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Estrogen Receptor Expression and its Relevant Signaling Pathway in Prostate Cancer: A Target of Therapy
Current Molecular Pharmacology