Abstract
The guanidine functional group is an important structural motif in synthesis with a wide range of interesting properties. Guanidines are frequently found in bioactive compounds; both from natural sources or from synthetic origin, these compounds are considered fundamental entities in medicinal chemistry. The relevance of these compounds fosters the efforts to explore new methodologies for the synthesis of substances based on the guanidine core. The aim of this review is to provide a survey of the types of reactions used to prepare these classes of compounds. Given the vast number of contributions to this topic, we have focused on the achievements made in the last five years and, in particular, in the synthesis of biologically relevant heterocyclic guanidine-derivatives.
Keywords: Bioactive compound, biological activities, guanidine, guanylating agents, heterocycle, synthesis.
Current Organic Chemistry
Title:Synthetic Approaches to Heterocyclic Guanidines with Biological Activity: An Update
Volume: 18 Issue: 21
Author(s): Sandra G. Zarate, Andres G. Santana, Agatha Bastida and Julia Revuelta
Affiliation:
Keywords: Bioactive compound, biological activities, guanidine, guanylating agents, heterocycle, synthesis.
Abstract: The guanidine functional group is an important structural motif in synthesis with a wide range of interesting properties. Guanidines are frequently found in bioactive compounds; both from natural sources or from synthetic origin, these compounds are considered fundamental entities in medicinal chemistry. The relevance of these compounds fosters the efforts to explore new methodologies for the synthesis of substances based on the guanidine core. The aim of this review is to provide a survey of the types of reactions used to prepare these classes of compounds. Given the vast number of contributions to this topic, we have focused on the achievements made in the last five years and, in particular, in the synthesis of biologically relevant heterocyclic guanidine-derivatives.
Export Options
About this article
Cite this article as:
Zarate G. Sandra, Santana G. Andres, Bastida Agatha and Revuelta Julia, Synthetic Approaches to Heterocyclic Guanidines with Biological Activity: An Update, Current Organic Chemistry 2014; 18 (21) . https://dx.doi.org/10.2174/1385272819666141002004054
DOI https://dx.doi.org/10.2174/1385272819666141002004054 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Non-viral Gene Delivery and Therapeutics Targeting to Brain
Current Nanoscience Heterogeneity Amongst 5-HT3 Receptor Subunits: Is this Significant?
Current Molecular Medicine Evolving Novel Chemical Entities for Management of Benign Prostatic Hyperplasia#
Mini-Reviews in Medicinal Chemistry Drug Targets in Infections with Other Emerging Viruses: Influenza Viruses, Metapneumovirus and Hantaviruses
Infectious Disorders - Drug Targets The Use of Propolis in Micro/Nanostructured Pharmaceutical Formulations
Recent Patents on Drug Delivery & Formulation Mechanisms of the Blunting of the Sympatho-Adrenal Response: A Theory
Current Diabetes Reviews Anti-Atherosclerotic Therapy Based on Botanicals
Recent Patents on Cardiovascular Drug Discovery Naturally Occurring and Related Synthetic Cannabinoids and their Potential Therapeutic Applications
Recent Patents on CNS Drug Discovery (Discontinued) A New Direction in Ophthalmic Development: Nanoparticle Drug Delivery Systems
Current Pharmaceutical Design Allergy to Miscellaneous Household Arthropods
Protein & Peptide Letters Sudden Infant Death Syndrome: Implications of Altered Physiological Control During Sleep
Current Pediatric Reviews Role of Heme Oxygenase-1 in Vascular Disease
Current Pharmaceutical Design Nimodipine Reappraised: An Old Drug With a Future
Current Neuropharmacology Exercise Induced Cardioprotection: An Overview of a Unique Form of Preconditioning
Current Cardiology Reviews The Use of N-Acetylcysteine in Respiratory Diseases
Current Respiratory Medicine Reviews Pharmacological Treatment of Hypertension in Pregnancy
Current Pharmaceutical Design A Review of Sodium Glucose Co-transporter 2 Inhibitors Canagliflozin, Dapagliflozin and Empagliflozin
Cardiovascular & Hematological Agents in Medicinal Chemistry Rho Kinase Inhibitors and Novel Ocular Drug Delivery Systems- A Revolutionary Step Towards the Treatment of Glaucoma
Current Drug Delivery Nothing But Stress – The Interplay of Angiotensin II, Inflammation, Hypertension and Atherosclerosis: Implications for Atherosclerotic Plaque Stability
Vascular Disease Prevention (Discontinued) Stable Gastric Pentadecapeptide BPC 157-NO-system Relation
Current Pharmaceutical Design