Abstract
This review describes the potential of a variety of physiologically active natural dietary polyphenols (PPhs) and their analogues, including derivatives of flavonoids, stilbenes, lignans, curcuminoids, and tannins, for prostate cancer chemotherapy. The large number of scientific papers on PPhs published during the last decade, particularly those focused on their therapeutic potential against prostate cancer cell lines, indicates rising interest in this group of compounds. Several polyphenolic agents are currently being investigated in advanced clinical trials as prominent cancer drug candidates while hundreds of related compounds are being evaluated in early clinical and preclinical studies. The review also covers the key mechanisms of antitumor action of natural PPhs against cancer cells.
Keywords: Chemotherapy, flavonoids, lignans, oncology, polyphenols, prostate cancer, stilbenes, tannins.
Current Bioactive Compounds
Title:Dietary Polyphenols for Prostate Cancer Therapy
Volume: 10 Issue: 2
Author(s): Yan A. Ivanenkov, Nina V. Chufarova, Mark S. Veselov and Alexander G. Majouga
Affiliation:
Keywords: Chemotherapy, flavonoids, lignans, oncology, polyphenols, prostate cancer, stilbenes, tannins.
Abstract: This review describes the potential of a variety of physiologically active natural dietary polyphenols (PPhs) and their analogues, including derivatives of flavonoids, stilbenes, lignans, curcuminoids, and tannins, for prostate cancer chemotherapy. The large number of scientific papers on PPhs published during the last decade, particularly those focused on their therapeutic potential against prostate cancer cell lines, indicates rising interest in this group of compounds. Several polyphenolic agents are currently being investigated in advanced clinical trials as prominent cancer drug candidates while hundreds of related compounds are being evaluated in early clinical and preclinical studies. The review also covers the key mechanisms of antitumor action of natural PPhs against cancer cells.
Export Options
About this article
Cite this article as:
Ivanenkov A. Yan, Chufarova V. Nina, Veselov S. Mark and Majouga G. Alexander, Dietary Polyphenols for Prostate Cancer Therapy, Current Bioactive Compounds 2014; 10 (2) . https://dx.doi.org/10.2174/157340721002141001102524
DOI https://dx.doi.org/10.2174/157340721002141001102524 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Study of Monocytes/Macrophages Stimuli as the Targets of Treating Inflammatory Bone Diseases
Current Drug Targets Radionuclide-Labeled Peptides for Imaging and Treatment of CXCR4- Overexpressing Malignant Tumors
Current Topics in Medicinal Chemistry Micro-/Nano-Scale Biointerfaces, Mechanical Coupling and Cancer Therapy
Current Topics in Medicinal Chemistry Insulin Delivery Systems for Controlling Diabetes
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Effects of Galbanic Acid on Proliferation, Migration, and Apoptosis of Glioblastoma Cells Through the PI3K/Akt/MTOR Signaling Pathway
Current Molecular Pharmacology Antiproliferative and Proapoptotic Effects of the TrK-inhibitor GW441756 in Human Myosarcomas and Prostatic Carcinoma
Current Signal Transduction Therapy Pluripotency Crossroads: Junction of Transcription Factors, Epigenetic Mechanisms, MicroRNAs, and Long Non-coding RNAs
Current Stem Cell Research & Therapy A Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical Correlates
Current Neuropharmacology 2', 4'-dihydroxy-3, 4-methylenedioxychalcone Activate Mitochondrial Apoptosis of Ehrlich Ascites Carcinoma Cells
Current Drug Therapy Drugs of Abuse: Epigenetic Mechanisms in Toxicity and Addiction
Current Medicinal Chemistry Gallium-68 – A New Opportunity For PET Available From a Long Shelflife Generator – Automation and Applications
Current Radiopharmaceuticals Recent Patents for Homologous Recombination Deficiency Assays Among Women with Ovarian Cancer
Recent Patents on Biotechnology Dutasteride in Androgenetic Alopecia: An Update
Current Clinical Pharmacology Hypoxia in Du-145 Prostate Cancer Xenografts After Estramustine Phosphate and Radiotherapy
Current Radiopharmaceuticals Evaluation of Current Pharmacological Treatment Options in the Management of Rett Syndrome: From the Present to Future Therapeutic Alternatives.
Current Clinical Pharmacology Targeted Toxins for Glioblastoma Multiforme: Pre-Clinical Studies and Clinical Implementation
Anti-Cancer Agents in Medicinal Chemistry The Medicinal Chemistry of Theragnostics, Multimodality Imaging and Applications of Nanotechnology in Cancer
Current Topics in Medicinal Chemistry Endocrinology and Immunology of Obesity, Obesity Vaccines
Current Clinical Pharmacology Theranostics of Metastatic Prostate Cancer Applying <sup>64</sup>Cu/<sup>18</sup>F/<sup>68</sup>Ga PSMA PET-CT and <sup>177</sup>Lu Radiopharmaceuticals
Current Radiopharmaceuticals Protein Kinase C and Prostate Carcinogenesis: Targeting the Cell Cycle and Apoptotic Mechanisms
Current Drug Targets