Cholinesterase Inhibition of Selected 4-Methylcoumarins in Comparison to their Antioxidant Activity

Title:Cholinesterase Inhibition of Selected 4-Methylcoumarins in Comparison to their Antioxidant Activity

Volume: 10 Issue: 4

Author(s): Sanja C. Zeljkovic, Zbigniew Czarnocki, Anna Zawadzka, Miroslawa Panasiewicz and Franci  Kovac

Affiliation:

Keywords: 4-Methylcoumarins, acetylcholinesterase, antioxidant activity, butyrylcholinesterase.

Abstract: Alzheimer’s disease (AD), a progressive neurodegenerative disease has become one of the major health issues in developed countries. Continuing our research on biological activity of coumarin derivatives, this study presents evaluation of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity of series 4- methylcoumarins. All studied compounds showed inhibitory activity in a similar manner as they are capable of scavenging reactive oxygen species and reducing transition metals. This study was focused on structural features that regulate biological activity of 4-methylcoumarins.

Cite this article as:

C. Zeljkovic Sanja, Czarnocki Zbigniew, Zawadzka Anna, Panasiewicz Miroslawa and Kovac Franci , Cholinesterase Inhibition of Selected 4-Methylcoumarins in Comparison to their Antioxidant Activity, Current Bioactive Compounds 2014; 10 (4) . https://dx.doi.org/10.2174/1573407210666141001000556