Abstract
Systemic sclerosis (scleroderma) is a heterogeneous autoimmune disorder characterized by collagen overproduction that leads to cutaneous and internal organs sclerosis and pulmonary arterial hypertension. SSc has high morbidity and mortality. SSc pathogenesis is uncertain. At present most therapies of SSc are symptomatic. Effective therapeutic approaches are lacking. Accompanying a growing understanding of SSc pathogenesis, various key mediators are being evaluated as the therapeutic targets. This review described the effects of these key mediators in SSc.
Keywords: Antibodies, biologics, fibrosis, pathogenesis, systemic sclerosis.
Current Pharmaceutical Biotechnology
Title:Biologics in Systemic Sclerosis
Volume: 15 Issue: 6
Author(s): Jingxiu Xuan, Long Shen, Chongjie Zhang and Julian L. Ambrus Jr.
Affiliation:
Keywords: Antibodies, biologics, fibrosis, pathogenesis, systemic sclerosis.
Abstract: Systemic sclerosis (scleroderma) is a heterogeneous autoimmune disorder characterized by collagen overproduction that leads to cutaneous and internal organs sclerosis and pulmonary arterial hypertension. SSc has high morbidity and mortality. SSc pathogenesis is uncertain. At present most therapies of SSc are symptomatic. Effective therapeutic approaches are lacking. Accompanying a growing understanding of SSc pathogenesis, various key mediators are being evaluated as the therapeutic targets. This review described the effects of these key mediators in SSc.
Export Options
About this article
Cite this article as:
Xuan Jingxiu, Shen Long, Zhang Chongjie and Jr. L. Ambrus Julian, Biologics in Systemic Sclerosis, Current Pharmaceutical Biotechnology 2014; 15 (6) . https://dx.doi.org/10.2174/138920101506140910150749
DOI https://dx.doi.org/10.2174/138920101506140910150749 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Review of Clinic Trials: Agents Targeting c-Met
Reviews on Recent Clinical Trials Cord Blood as Diagnostic Window for Preeclampsia
Recent Patents on Biomarkers Taste and Hypertension in Humans: Targeting Cardiovascular Disease
Current Pharmaceutical Design Editorial: Management of Diabetes in Unique Populations
Current Diabetes Reviews The Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Cardiovascular Homeostasis: A Non-Systematic Literature Review
Current Cardiology Reviews Endothelin-Converting Enzyme Inhibitors
Current Enzyme Inhibition Role of Hyperglycaemia in Pathogenesis of Diabetic Cardiovascular Disease
Vascular Disease Prevention (Discontinued) Lipoprotein (a) and Cardiovascular Risk: The Show Must go on
Current Medicinal Chemistry Glucocorticoid-Induced Hypertension and Tetrahydrobiopterin (BH4), a Common Cofactor for the Production of Vasoactive Molecules
Current Hypertension Reviews Combination of Statin Plus Renin Angiotensin System Inhibition for the Prevention or the Treatment of Atherosclerotic Cardiovascular Disease
Current Pharmaceutical Design Radial Distribution of Elasticity in Porcine Thoracic Aorta
Vascular Disease Prevention (Discontinued) Gene Modified Cell Transplantation for Vascular Regeneration
Current Gene Therapy A Link Between Hypertension and Atrial Fibrillation: Methods of Treatment and Prevention
Current Vascular Pharmacology A Review of the Role of Statins in Heart Failure Treatment
Current Clinical Pharmacology Pharmacogenomics: Integration into Drug Discovery and Development
Current Topics in Medicinal Chemistry Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium
Current Pharmaceutical Design Resilience to Alzheimer's Disease: The Role of Physical Activity
Current Alzheimer Research Nitric Oxide and Protection against Cardiac Ischemia
Current Pharmaceutical Design Role of Asymmetric Dimethylarginine in Cardiorenal Syndrome
Current Pharmaceutical Design Fluorescent Probes for Cellular Assays
Combinatorial Chemistry & High Throughput Screening