Abstract
As important members of the terpenes family, sesquiterpenes represent a group of natural compounds with diverse skeletal types. Among them, the eremophilane-type sesquiterpenes, widely present in several genera (such as Ligularia, Senecio, Cacalia) of Asteraceae, account for a small number of natural compounds and form differently from other sesquiterpenes because they challenged the isoprene rule of biosynthesis. Due to the unique structural features and various functional groups, these compounds possess a number of biological activities such as anti-tumor, anti-bacterial and anti-inflammatory, having received increasing interest in the recent years. This review summarizes the occurrence of eremophilane-type sesquiterpenes and research progresses on their biological activities since the 1990s.
Keywords: Anti-tumor, anti-microbial, anti-inflammatory, anti-allergy, eremophilane-type sesquiterpenes.
Mini-Reviews in Medicinal Chemistry
Title:Occurrence and Biological Activities of Eremophilane-type Sesquiterpenes
Volume: 14 Issue: 8
Author(s): Chenjie Hou, Marianna Kulka, Junzeng Zhang, Yiming Li and Fujiang Guo
Affiliation:
Keywords: Anti-tumor, anti-microbial, anti-inflammatory, anti-allergy, eremophilane-type sesquiterpenes.
Abstract: As important members of the terpenes family, sesquiterpenes represent a group of natural compounds with diverse skeletal types. Among them, the eremophilane-type sesquiterpenes, widely present in several genera (such as Ligularia, Senecio, Cacalia) of Asteraceae, account for a small number of natural compounds and form differently from other sesquiterpenes because they challenged the isoprene rule of biosynthesis. Due to the unique structural features and various functional groups, these compounds possess a number of biological activities such as anti-tumor, anti-bacterial and anti-inflammatory, having received increasing interest in the recent years. This review summarizes the occurrence of eremophilane-type sesquiterpenes and research progresses on their biological activities since the 1990s.
Export Options
About this article
Cite this article as:
Hou Chenjie, Kulka Marianna, Zhang Junzeng, Li Yiming and Guo Fujiang, Occurrence and Biological Activities of Eremophilane-type Sesquiterpenes, Mini-Reviews in Medicinal Chemistry 2014; 14 (8) . https://dx.doi.org/10.2174/1389557514666140820105422
DOI https://dx.doi.org/10.2174/1389557514666140820105422 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cerebrovascular Profile Assessment in Parkinson's Disease Patients
CNS & Neurological Disorders - Drug Targets Stroke and Hypertension: An Appraisal from Pathophysiology to Clinical Practice
Current Vascular Pharmacology Unsafe Abortion: The Silent Endemic; An Avoidable Cause of Maternal Mortality. A Review
Current Women`s Health Reviews Nerve Injury Associated with Regional Anesthesia
Current Topics in Medicinal Chemistry Treating COPD in Older and Oldest Old Patients
Current Pharmaceutical Design Invasive Aspergillosis: New Insights into Disease, Diagnostic and Treatment
Current Pharmaceutical Design Secondary Hypertension: The Ways of Management
Current Vascular Pharmacology Role of the Renin-Angiotensin-Aldosterone System in the Pathogenesis of Atherosclerosis
Current Pharmaceutical Design Meet Our Associate Editor
Current Molecular Medicine Peptide Therapeutics in Neurodegenerative Disorders
Current Medicinal Chemistry Pharmacological and Biological Activities of Xanthones
Anti-Infective Agents in Medicinal Chemistry Low Doses of G-CSF Prevent Cerebral Infarction and Maintain Muscle Strength in an Experimental Model of Global Ischemic Stroke
Current Pharmaceutical Biotechnology Stage A: Can Heart Failure Be Prevented?
Current Cardiology Reviews Potential Novel Anxiolytic Drugs
Current Pharmaceutical Design Chemical and Potential Biological Perspectives of Genus Sarcococca (Buxaceae)
The Natural Products Journal Snake Venom Prothrombin Activators Similar to Blood Coagulation Factor Xa
Current Drug Targets - Cardiovascular & Hematological Disorders Reversal of Resistance to Oxazaphosphorines
Current Cancer Drug Targets Classical and New Renin-Angiotensin Signalling in Atherosclerosis
Current Signal Transduction Therapy Crystallization and Preliminary Crystallographic Studies of an Antitumour Lectin from the Edible Mushroom Agrocybe aegerita
Protein & Peptide Letters Anxiety: A Systematic Review of Neurobiology, Traditional Pharmaceuticals and Novel Alternatives from Medicinal Plants
CNS & Neurological Disorders - Drug Targets