Abstract
Proteases regulating inflammation are versatile enzymes, usually extracellular matrix degrading enzymes that are involved in wound healing, angiogenesis, coagulation, development, apoptosis and other physiological processes. Their dysregulation and increased expression during inflammation can have devastating consequences, promoting etiology of vascular diseases, inflammatory arthritis, cancer, and allograft rejection. In this review several proteases (ADAMTS, granzymes, plasmin, and kallikreins) with different mechanisms and substrates are described in addition to their physiological roles and contribution to inflammation and inflammatory diseases. Inhibition of proteases may therefore represent an attractive strategy for treatment and herein we describe physiological and engineered inhibitors.
Keywords: ADAMTS, granzymes, inflammation, inhibitors, kallikreins, (patho)physiology, plasmin, proteases.
Protein & Peptide Letters
Title:Inflammation-Mediating Proteases: Structure, Function in (Patho) Physiology and Inhibition
Volume: 21 Issue: 12
Author(s): Mateja Mancek-Keber
Affiliation:
Keywords: ADAMTS, granzymes, inflammation, inhibitors, kallikreins, (patho)physiology, plasmin, proteases.
Abstract: Proteases regulating inflammation are versatile enzymes, usually extracellular matrix degrading enzymes that are involved in wound healing, angiogenesis, coagulation, development, apoptosis and other physiological processes. Their dysregulation and increased expression during inflammation can have devastating consequences, promoting etiology of vascular diseases, inflammatory arthritis, cancer, and allograft rejection. In this review several proteases (ADAMTS, granzymes, plasmin, and kallikreins) with different mechanisms and substrates are described in addition to their physiological roles and contribution to inflammation and inflammatory diseases. Inhibition of proteases may therefore represent an attractive strategy for treatment and herein we describe physiological and engineered inhibitors.
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Cite this article as:
Mancek-Keber Mateja, Inflammation-Mediating Proteases: Structure, Function in (Patho) Physiology and Inhibition, Protein & Peptide Letters 2014; 21 (12) . https://dx.doi.org/10.2174/0929866521666140819123932
DOI https://dx.doi.org/10.2174/0929866521666140819123932 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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