Abstract
Dramatic advancement in the field of oral delivery of biomacromolecules occurred within the last decades. Recently, a novel class of multifunctional polymers has risen in the pharmaceutical literature. These thiolated polymers designated thiomers are based on a variety of well-known polymers such as alginate, poly(acrylic acid) or chitosan. They are synthesized via covalent attachment of sulfhydryl group bearing ligands to the polymeric backbone. Forming disulfide bonds with mucus substructures, these thiomers offer the advantage of more pronounced mucoadhesive features in comparison with their unmodified polymers. This review enhances a comprehensive insight on thiomers history, mucoadhesion process as a complex phenomenon and oral drug delivery of biomacromolecules.
Keywords: Mucoadhesion, mucosa, oral delivery, polymers, thiomers.
Current Drug Therapy
Title:Thiomers, Mucoadhesion and Oral Delivery of Biomacromolecules
Volume: 9 Issue: 1
Author(s): Flavia Laffleur
Affiliation:
Keywords: Mucoadhesion, mucosa, oral delivery, polymers, thiomers.
Abstract: Dramatic advancement in the field of oral delivery of biomacromolecules occurred within the last decades. Recently, a novel class of multifunctional polymers has risen in the pharmaceutical literature. These thiolated polymers designated thiomers are based on a variety of well-known polymers such as alginate, poly(acrylic acid) or chitosan. They are synthesized via covalent attachment of sulfhydryl group bearing ligands to the polymeric backbone. Forming disulfide bonds with mucus substructures, these thiomers offer the advantage of more pronounced mucoadhesive features in comparison with their unmodified polymers. This review enhances a comprehensive insight on thiomers history, mucoadhesion process as a complex phenomenon and oral drug delivery of biomacromolecules.
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Cite this article as:
Laffleur Flavia, Thiomers, Mucoadhesion and Oral Delivery of Biomacromolecules, Current Drug Therapy 2014; 9 (1) . https://dx.doi.org/10.2174/1574885509666140805004423
DOI https://dx.doi.org/10.2174/1574885509666140805004423 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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