Abstract
A diastereoselective synthesis of functionalised tetrahydroquinolines was performed using a one-pot imino Diels-Alder cycloaddition reaction of anilines, benzaldehydes and isoeugenol at room temperature using propylene carbonate as an environmentally friendly solvent and molecular iodine as an efficient catalyst. This new protocol has the advantages of higher yields, mild conditions, simple methodology, a short reaction time and a straightforward work-up. Propylene carbonate served as an alternative solvent to the organic solvents commonly used for this reaction, e.g., CH2Cl2, DMF, and MeCN.
Keywords: Diels-Alder, green chemistry, Povarov Reaction, propylene carbonate, tetrahydroquinoline.
Graphical Abstract
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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