Abstract
Alterations of the cardiac autonomic nervous system play an important role in the pathway of many heart diseases. Nuclear imaging tools have been demonstrated to be useful for global and regional assessment of myocardial innervation. We used 11C-meta-hydroxy-ephedrine (11C-mHED), a catecholamine analogue, as a radiotracer usable with a PET/CT scanner to study the cardiac sympathetic system. After a fast and automatic synthesis of mHED and its labeling with 11C, we acquired cardiac images by using a PET/ CT scanner. In this paper we present our preliminary results showing the radiotracer bio-distribution in humans 10 minutes post injection. The present study assesses the feasibility of PET/CT with the radiolabeled catecholamine analogue (11C-mHED) in order to determine sympathetic innervation in the human heart.
Keywords: 11C -meta-hydroxy-ephedrine, cardiac imaging, norepinephrine, sympathetic innervations.
Current Radiopharmaceuticals
Title:11C-mHED for PET / CT: Principles of Synthesis, Methodology and First Clinical Applications
Volume: 7 Issue: 2
Author(s): Rachele Bonfiglioli, Cristina Nanni, Cristian Martignani, Lucia Zanoni, Raffaele La Donna, Igor Diemberger, Giuseppe Boriani, Cinzia Pettinato, Gianmario Sambuceti, Stefano Fanti and Luigi Mansi
Affiliation:
Keywords: 11C -meta-hydroxy-ephedrine, cardiac imaging, norepinephrine, sympathetic innervations.
Abstract: Alterations of the cardiac autonomic nervous system play an important role in the pathway of many heart diseases. Nuclear imaging tools have been demonstrated to be useful for global and regional assessment of myocardial innervation. We used 11C-meta-hydroxy-ephedrine (11C-mHED), a catecholamine analogue, as a radiotracer usable with a PET/CT scanner to study the cardiac sympathetic system. After a fast and automatic synthesis of mHED and its labeling with 11C, we acquired cardiac images by using a PET/ CT scanner. In this paper we present our preliminary results showing the radiotracer bio-distribution in humans 10 minutes post injection. The present study assesses the feasibility of PET/CT with the radiolabeled catecholamine analogue (11C-mHED) in order to determine sympathetic innervation in the human heart.
Export Options
About this article
Cite this article as:
Bonfiglioli Rachele, Nanni Cristina, Martignani Cristian, Zanoni Lucia, Donna La Raffaele, Diemberger Igor, Boriani Giuseppe, Pettinato Cinzia, Sambuceti Gianmario, Fanti Stefano and Mansi Luigi, 11C-mHED for PET / CT: Principles of Synthesis, Methodology and First Clinical Applications, Current Radiopharmaceuticals 2014; 7 (2) . https://dx.doi.org/10.2174/1874471007666140714111304
DOI https://dx.doi.org/10.2174/1874471007666140714111304 |
Print ISSN 1874-4710 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4729 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Role of Nitrosative Stress and Peroxynitrite in the Pathogenesis of Diabetic Complications. Emerging New Therapeutical Strategies
Current Medicinal Chemistry Is the Vascular System a Main Target for Thyroid Hormones? From Molecular and Biochemical Findings to Clinical Perspectives
Current Vascular Pharmacology The Involvement of PPARs in the Causes, Consequences and Mechanisms for Correction of Cardiac Lipotoxicity and Oxidative Stress
Current Molecular Pharmacology Mitochondrial Oxidative Stress and Heart Failure ∼Novel Pathophysiological Insight and Treatment Strategies∼
Current Cardiology Reviews Pharmacokinetic Considerations of Perinatal Antiretroviral Therapy
Current Drug Metabolism Remodeling of the Myocardium and Potential Targets in the Collagen Degradation and Synthesis Pathways
Current Drug Targets - Cardiovascular & Hematological Disorders Cardiovascular Manifestations of COVID-19
Current Cardiology Reviews Editorial [Hot Topic : Current Practice and trends in echocardiography in Critical Care, Anesthesiology and Emergency Medicine (Guest Editor: Paulo Marcelino)]
Current Cardiology Reviews Stable Gastric Pentadecapeptide BPC 157-NO-system Relation
Current Pharmaceutical Design Pathophysiology of Diabetic Secondary Complication and their Management
Current Diabetes Reviews Titin and Troponin: Central Players in the Frank-Starling Mechanism of the Heart
Current Cardiology Reviews G Protein-Coupled Receptor Kinase 2 - a Feedback Regulator of Gq Pathway Signalling
Current Drug Targets - Immune, Endocrine & Metabolic Disorders “Endothelial Progenitor Cells” as a Therapeutic Strategy in Cardiovascular Disease
Current Vascular Pharmacology Heart Failure Models: Traditional and Novel Therapy
Current Vascular Pharmacology Inflammation, Oxidation, Caloric Expenditure and Cognitive Impairment in Brazilian Elderly Assisted at Primary Care
Current Alzheimer Research A Critical and Comprehensive Insight on Heme Oxygenase and Related Products Including Carbon Monoxide, Bilirubin, Biliverdin and Ferritin in Type-1 and Type-2 Diabetes
Current Pharmaceutical Design Cardiac Complications Attributed to Hydroxychloroquine: A Systematic Review of the Literature Pre-COVID-19
Current Cardiology Reviews Renal Nerve Ablation for Hypertensive Patients with Chronic Kidney Disease
Current Vascular Pharmacology SynB3 Conjugated QBP1 Passes Blood-Brain Barrier Models and Inhibits PolyQ Protein Aggregation
Protein & Peptide Letters Synthetic Peptides in the Diagnosis of Systemic Autoimmune Diseases
Current Protein & Peptide Science