Abstract
Tuberculosis (TB) is a major cause of illness and death. The worldwide epidemic of HIV/AIDS and emergence of multidrug-resistant and extensively drug-resistant TB, are exacerbating this global public health issue. In this situation, several innovative approaches are being pursued to further improve the existing measures, as well as to identify new one. Recently, stem cell transplantation has emerged as a novel therapeutic option which holds promises for the treatment of many non-infectious and infectious diseases. Recent advances and experimental studies attracted the interest of researchers for exploring the stem cellbased treatment as a candidate treatment option for drug resistant tuberculosis. To date little has been published concerning the short and long term therapeutic effect of any type of stem cells in patients suffering from drug resistant tuberculosis. The purpose of this review is to present the viewpoints on current status and future prospect of this novel treatment approach in severe form of TB and also to discuss the opportunities and challenges associated with this approach.
Keywords: Extensively drug resistant tuberculosis, multidrug resistant tuberculosis, mesenchymal stem cells, Mycobacterium tuberculosis, stem cells, tuberculosis.
Current Respiratory Medicine Reviews
Title:Progress and Prospects of Stem Cells in Treatment of Drug Resistant Tuberculosis
Volume: 10 Issue: 4
Author(s): Pravin Kumar Singh and Amita Jain
Affiliation:
Keywords: Extensively drug resistant tuberculosis, multidrug resistant tuberculosis, mesenchymal stem cells, Mycobacterium tuberculosis, stem cells, tuberculosis.
Abstract: Tuberculosis (TB) is a major cause of illness and death. The worldwide epidemic of HIV/AIDS and emergence of multidrug-resistant and extensively drug-resistant TB, are exacerbating this global public health issue. In this situation, several innovative approaches are being pursued to further improve the existing measures, as well as to identify new one. Recently, stem cell transplantation has emerged as a novel therapeutic option which holds promises for the treatment of many non-infectious and infectious diseases. Recent advances and experimental studies attracted the interest of researchers for exploring the stem cellbased treatment as a candidate treatment option for drug resistant tuberculosis. To date little has been published concerning the short and long term therapeutic effect of any type of stem cells in patients suffering from drug resistant tuberculosis. The purpose of this review is to present the viewpoints on current status and future prospect of this novel treatment approach in severe form of TB and also to discuss the opportunities and challenges associated with this approach.
Export Options
About this article
Cite this article as:
Kumar Singh Pravin and Jain Amita, Progress and Prospects of Stem Cells in Treatment of Drug Resistant Tuberculosis, Current Respiratory Medicine Reviews 2014; 10 (4) . https://dx.doi.org/10.2174/1573398X10666140701175259
DOI https://dx.doi.org/10.2174/1573398X10666140701175259 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Review of Current Chemoinformatic Tools for Modeling Important Aspects of CYPsmediated Drug Metabolism. Integrating Metabolism Data with Other Biological Profiles to Enhance Drug Discovery
Current Drug Metabolism Coumarin Derivatives as Adjuvants: From In Silico Physicochemical Characterization to In Vitro Evaluation against Gram Positive Bacteria
Combinatorial Chemistry & High Throughput Screening Natural Product-Derived Small Molecule Activators of Hypoxia-Inducible Factor-1 (HIF-1)
Current Pharmaceutical Design Mechanism-based Modulator Discovery for Sirtuin-catalyzed Deacetylation Reaction
Mini-Reviews in Medicinal Chemistry Adverse Drug Reactions Amongst Adult Patients Admitted in Lagos State University Teaching Hospital Lagos, Nigeria
Current Drug Safety 1, 2, 4-triazoles Clubbed Pyrimidine Compounds with Synthesis, Antimicrobial, Antituberculosis, Antimalarial, and Anti-protozoal Studies
Letters in Organic Chemistry Choice of Biologic Therapy for Patients with Rheumatoid Arthritis: The Infection Perspective
Current Rheumatology Reviews Artemisia Species as Potential Weapon Against Agents and Agricultural Pests
Current Biotechnology Real-Time PCR: Revolutionizing Detection and Expression Analysis of Genes
Current Genomics Mitogen-Induced Interferon Gamma Production in Human Whole Blood: The Effect of Heat and Cations
Current Pharmaceutical Biotechnology Nine Medico-Legal Pitfalls in Inflammatory Bowel Disease in the United States
Current Drug Targets Utility of Non-Conventional Applications of Anti-VEGF Treatment in Selected Retinal Diseases
Current Drug Therapy The CD4C/HIVNef Transgenic Model of AIDS
Current HIV Research The Potential of Natural Diterpenes Against Tuberculosis: An Updated Review
Current Pharmaceutical Design Nutritional and Therapeutic Potential of Garlic and Onion (Allium sp.)
Current Nutrition & Food Science Insight View on Possible Role of Fluoroquinolones in Cancer Therapy
Current Topics in Medicinal Chemistry Leukocyte P2 Receptors: A Novel Target for Anti-inflammatory and Antitumor Therapy
Current Drug Targets - Cardiovascular & Hematological Disorders Editorial [Tuberculosis Drugs and Drug Targets]
Infectious Disorders - Drug Targets Rashes, Sniffles, and Stroke: A Role for Infection in Ischemic Stroke of Childhood
Infectious Disorders - Drug Targets Drug Repurposing: An Emerging Tool for Drug Reuse, Recycling and Discovery
Current Drug Research Reviews