Abstract
Type-2 diabetes (T2D) is a complex metabolic syndrome that is characterized by persistent hyperglycemia due to either lack of insulin secretion and/or insulin resistance. The prevalence of T2D along with its major risk factor, obesity, has been increasing with an epidemic proportion in recent years. To date, there is no drug of cure for diabetes and the existing therapeutic approaches have serious drawbacks including side effects and loss of efficacy during prolonged use. Dietary polyphenols are one group of natural products that have shown promise as potential antidiabetic agents. In this review, their molecular mechanisms of action including, antioxidant, anti-inflammatory, receptor agonist/antagonist effect and modulation of key signal transduction cascades, glucose transport, enzyme activity, receptor agonistic/antagonist effect, etc. in major insulin-sensitive cells are discussed.
Keywords: Anti-inflammatory, antioxidant, diabetes, enzyme inhibition, fatty acids metabolism, glucose metabolism, polyphenols, receptor modulation.
Current Pharmaceutical Biotechnology
Title:The Antidiabetic Therapeutic Potential of Dietary Polyphenols
Volume: 15 Issue: 4
Author(s): Solomon Habtemariam and George K. Varghese
Affiliation:
Keywords: Anti-inflammatory, antioxidant, diabetes, enzyme inhibition, fatty acids metabolism, glucose metabolism, polyphenols, receptor modulation.
Abstract: Type-2 diabetes (T2D) is a complex metabolic syndrome that is characterized by persistent hyperglycemia due to either lack of insulin secretion and/or insulin resistance. The prevalence of T2D along with its major risk factor, obesity, has been increasing with an epidemic proportion in recent years. To date, there is no drug of cure for diabetes and the existing therapeutic approaches have serious drawbacks including side effects and loss of efficacy during prolonged use. Dietary polyphenols are one group of natural products that have shown promise as potential antidiabetic agents. In this review, their molecular mechanisms of action including, antioxidant, anti-inflammatory, receptor agonist/antagonist effect and modulation of key signal transduction cascades, glucose transport, enzyme activity, receptor agonistic/antagonist effect, etc. in major insulin-sensitive cells are discussed.
Export Options
About this article
Cite this article as:
Habtemariam Solomon and Varghese K. George, The Antidiabetic Therapeutic Potential of Dietary Polyphenols, Current Pharmaceutical Biotechnology 2014; 15 (4) . https://dx.doi.org/10.2174/1389201015666140617104643
DOI https://dx.doi.org/10.2174/1389201015666140617104643 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Recent Developments on Endothelin Antagonists as Immunomodulatory Drugs - from Infection to Transplantation Medicine
Recent Patents on Cardiovascular Drug Discovery Current Evidence from Phase III Clinical Trials of Selenium Supplementation in Critically Ill Patients: Why Should We Bother?
Mini-Reviews in Medicinal Chemistry GLP - 1 Analogs: Newer Molecules, Newer Uses
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Safety Analysis and Improved Cardiac Function Following Local Autologous Transplantation of CD133+ Enriched Bone Marrow Cells After Myocardial Infarction
Current Neurovascular Research Aetiology, Diagnosis and Treatment of Hydrops Foetalis
Current Pediatric Reviews Future Therapeutic Strategies in Inflammatory Cardiomyopathy: Insights from the Experimental Autoimmune Myocarditis Model
Cardiovascular & Hematological Disorders-Drug Targets A Review on Electrocardiographic Changes in Diabetic Patients
Current Diabetes Reviews The STAT3 Inhibitor Stattic Impairs Cardiomyocyte Mitochondrial Function Through Increased Reactive Oxygen Species Formation
Current Pharmaceutical Design Modulation of Fatty Acids Oxidation in Heart Failure by Selective Pharmacological Inhibition of 3-Ketoacyl Coenzyme-A Thiolase
Current Clinical Pharmacology INNO-206 (DOXO-EMCH), an Albumin-Binding Prodrug of Doxorubicin Under Development for Phase II Studies
Current Bioactive Compounds Forensic Toxicology and Pharmacogenomics: Hype or Hope For Higher Standards in Forensic Medicine?
Current Pharmacogenomics and Personalized Medicine Cardiac Specific Overexpression of hHole Attenuates Isoproterenol–Induced Hypertrophic Remodeling through Inhibition of Extracellular Signal-Regulated Kinases (ERKs) Signalling
Current Molecular Medicine Engineered Nanoparticles Against MDR in Cancer: The State of the Art and its Prospective
Current Pharmaceutical Design The Genetics of Small-Vessel Disease
Current Medicinal Chemistry The Anti-fibrotic Hormone Relaxin is not Reno-protective, Despite Being Active, in an Experimental Model of Type 1 Diabetes
Protein & Peptide Letters New Insights into HLA-G and Inflammatory Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Device Therapies: New Indications and Future Directions
Current Cardiology Reviews Functional Imaging Combined with Multi-Detector CT: A Radionuclide Imaging Perspective
Current Medical Imaging Radioligands for the Angiotensin II Subtype 1 (AT1) Receptor
Current Topics in Medicinal Chemistry A Review of Therapeutic Effects of Curcumin
Current Pharmaceutical Design