Abstract
Biomacromolecules play an important role in the treatment of many diseases, but their topical application has been limited by their poor cell membrane permeability. Cell-penetrating peptides (CPPs) have been investigated over the past few decades as a potential strategy to overcome this challenge. CPPs can effectively mediate the cellular uptake of poorly internalized biomacromolecules without unfavorable side effects and have therefore attracted considerable interest as a viable alternative to existing parenteral therapies involving biomacromolecules. In this review, we will highlight the application of CPPs to the non-invasive delivery of biomacromolecules, with a focus on percutaneous and nasal absorption of biomacromolecules administered using CPPs.
Keywords: Biomacromolecules, cell-penetrating peptide, intranasal delivery, non-invasive delivery, percutaneous delivery, topical administration.
Current Pharmaceutical Biotechnology
Title:Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs
Volume: 15 Issue: 3
Author(s): Jiao Tan, Heesun Cheong, Yoon Shin Park, Hangun Kim, Meng Zhang, Cheol Moon and Yongzhuo Huang
Affiliation:
Keywords: Biomacromolecules, cell-penetrating peptide, intranasal delivery, non-invasive delivery, percutaneous delivery, topical administration.
Abstract: Biomacromolecules play an important role in the treatment of many diseases, but their topical application has been limited by their poor cell membrane permeability. Cell-penetrating peptides (CPPs) have been investigated over the past few decades as a potential strategy to overcome this challenge. CPPs can effectively mediate the cellular uptake of poorly internalized biomacromolecules without unfavorable side effects and have therefore attracted considerable interest as a viable alternative to existing parenteral therapies involving biomacromolecules. In this review, we will highlight the application of CPPs to the non-invasive delivery of biomacromolecules, with a focus on percutaneous and nasal absorption of biomacromolecules administered using CPPs.
Export Options
About this article
Cite this article as:
Tan Jiao, Cheong Heesun, Park Shin Yoon, Kim Hangun, Zhang Meng, Moon Cheol and Huang Yongzhuo, Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs, Current Pharmaceutical Biotechnology 2014; 15 (3) . https://dx.doi.org/10.2174/1389201015666140617094320
DOI https://dx.doi.org/10.2174/1389201015666140617094320 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate and Related Steroids: Their Role in Inflammatory, Allergic and Immunological Disorders
Current Drug Targets - Inflammation & Allergy Targeting the Spindle Assembly Checkpoint for Breast Cancer Treatment
Current Cancer Drug Targets Anti-Cancer Drugs of Today and Tomorrow: Are we Close to Making the Turn from Treating to Curing Cancer?
Current Pharmaceutical Design The PIK3CA Gene as a Mutated Target for Cancer Therapy
Current Cancer Drug Targets Assessment of Retinal Structural and Functional Characteristics in Eyes with Autoimmune Retinopathy
Current Molecular Medicine Regulatory Circuitries Coordinated by Transcription Factors and microRNAs at the Cornerstone of Hematopoietic Stem Cell Self-Renewal and Differentiation
Current Stem Cell Research & Therapy Polyphenols: Skin Photoprotection and Inhibition of Photocarcinogenesis
Mini-Reviews in Medicinal Chemistry Glycyrrhetinic Acid and Its Derivatives: Anti-Cancer and Cancer Chemopreventive Properties, Mechanisms of Action and Structure- Cytotoxic Activity Relationship
Current Medicinal Chemistry Characterization of Induced Pluripotent Stem Cells from Human Epidermal Melanocytes by Transduction with Two Combinations of Transcription Factors
Current Gene Therapy Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis
Current Bioinformatics Oncolytic Virus: Regulatory Aspects from Quality Control to Clinical Studies
Current Cancer Drug Targets Polymer Particulates in Drug Delivery
Current Pharmaceutical Design Financial Returns on R&D: Looking Back at History, Looking Forward to Adaptive Licensing
Reviews on Recent Clinical Trials Management of Vulvar Cancer
Reviews on Recent Clinical Trials Pharmacokinetic Profiles of Anticancer Herbal Medicines in Humans and the Clinical Implications
Current Medicinal Chemistry Anti-infective Agents Produced by the Hyphomycetes Genera Trichoderma and Gliocladium
Current Medicinal Chemistry - Anti-Infective Agents Telomerase as Drug and Drug Target for the Treatment of Thyroid Cancer
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Genetic and Molecular Approaches to the Immunopathogenesis of Multiple Sclerosis: An Update
Current Molecular Medicine Anti-Seizure Medications and Estradiol for Neuroprotection in Epilepsy: The 2013 Update
Recent Patents on CNS Drug Discovery (Discontinued) Steroid Biosynthesis Inhibitors in the Therapy of Hypercortisolism: Theory and Practice
Current Medicinal Chemistry