Abstract
Previous studies suggested that microRNAs (miRNAs) participate in almost all cellular processes and the continuous development of miRNA-mediated posttranscriptional regulation might have facilitated the development of complex organisms. Especially, the microRNA-22 (miR-22) family has been recently extensively reported. Here, we accessed the evolution of miR-22 structure, regulation, and targets, and this indicated that miR-22 plays key roles in more complex organisms. We demonstrated that the miR-22 family arose approximate 600 million years ago from the latest common ancestor of bilaterians. Moreover, a survey of genomic contexts and the secondary structure of the miR-22 family revealed that it originated de novo from a relatively conserved intron region, and the mature sequence of the miR-22 family evolved by seed pairing with highly conserved 3' "U" and 5' "G" boundaries. Furthermore, a complete picture of the evolution of the regulatory networks associated with miR-22 was obtained from the analysis of experimentally identified, as well as computationally predicted, functional targets of miR-22.
Keywords: Evolution, microRNA, miR-22, origin, phylogeny, taxonomy.
MicroRNA
Title:Key Roles of MicroRNA-22 Family in Complex Organisms Inferred from its Evolution
Volume: 3 Issue: 1
Author(s): Jianhua Xiong
Affiliation:
Keywords: Evolution, microRNA, miR-22, origin, phylogeny, taxonomy.
Abstract: Previous studies suggested that microRNAs (miRNAs) participate in almost all cellular processes and the continuous development of miRNA-mediated posttranscriptional regulation might have facilitated the development of complex organisms. Especially, the microRNA-22 (miR-22) family has been recently extensively reported. Here, we accessed the evolution of miR-22 structure, regulation, and targets, and this indicated that miR-22 plays key roles in more complex organisms. We demonstrated that the miR-22 family arose approximate 600 million years ago from the latest common ancestor of bilaterians. Moreover, a survey of genomic contexts and the secondary structure of the miR-22 family revealed that it originated de novo from a relatively conserved intron region, and the mature sequence of the miR-22 family evolved by seed pairing with highly conserved 3' "U" and 5' "G" boundaries. Furthermore, a complete picture of the evolution of the regulatory networks associated with miR-22 was obtained from the analysis of experimentally identified, as well as computationally predicted, functional targets of miR-22.
Export Options
About this article
Cite this article as:
Xiong Jianhua, Key Roles of MicroRNA-22 Family in Complex Organisms Inferred from its Evolution, MicroRNA 2014; 3 (1) . https://dx.doi.org/10.2174/2211536603666140609232335
DOI https://dx.doi.org/10.2174/2211536603666140609232335 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
Call for Papers in Thematic Issues
Modulatory Roles of Non-coding RNAs in cancer therapy
This thematic issue aims to elucidate the most recent research on ncRNAs in CRCs and discuss the importance and difficulties that may arise in applying this tool on a regular clinical basis.read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Impact of Cellular Senescence in Aging and Cancer
Current Pharmaceutical Design Free Flap Head and Neck Reconstruction After Cancer Therapy: Current State of the Art
Current Cancer Therapy Reviews A Systems Biology Road Map for the Discovery of Drugs Targeting Cancer Cell Metabolism
Current Pharmaceutical Design Thyroid Function and Obesity: From Mechanisms to the Benefits of Levothyroxine in Obese Patients
Endocrine, Metabolic & Immune Disorders - Drug Targets Circulating Nucleic Acids in Plasma and Serum: Roles in Diagnosis and Prognosis in Diabetes and Cancer
Infectious Disorders - Drug Targets <i>Nigella sativa</i> – A Functional Spice From A Pharaoh’s Tomb to Modern Healthcare
The Natural Products Journal Channel-Like Functions of the 18-kDa Translocator Protein (TSPO): Regulation of Apoptosis and Steroidogenesis as Part of the Host-Defense Response
Current Pharmaceutical Design Targeting Tumor Proteasome with Traditional Chinese Medicine
Current Drug Discovery Technologies Targeting Tumor Microenvironment with Silibinin: Promise and Potential for a Translational Cancer Chemopreventive Strategy
Current Cancer Drug Targets 5-HT3 Receptors
Current Drug Targets - CNS & Neurological Disorders Mechanism of Action and Therapeutic Potential of Novel Adamantyl Retinoid-Related Molecules
Current Cancer Therapy Reviews HPV as a Model for the Development of Prophylactic and Therapeutic Cancer Vaccines
Current Molecular Medicine Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Synthesis of 9-O-3-(1-piperazinyl/morpholinyl/piperidinyl)pentyl-berberines as Potential Antioxidant and Cytotoxic Agents
Anti-Cancer Agents in Medicinal Chemistry Lemon Juice as a Biocatalyst Under Ultrasound Irradiation: Synthesis and Pharmacological Evaluation of 2-amino 1,3,4-thiadiazoles
Anti-Cancer Agents in Medicinal Chemistry Antineoplastic Potential of Medicinal Plants
Recent Patents on Biotechnology SCYL1-BP1 Affects Cell Cycle Arrest in Human Hepatocellular Carcinoma Cells via Cyclin F and RRM2
Anti-Cancer Agents in Medicinal Chemistry The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein
Current Medicinal Chemistry Neurological Complications of Anderson-Fabry Disease
Current Pharmaceutical Design Editorial: Signalling Pathways in Virus-caused Cancers
Current Cancer Drug Targets