Abstract
Leukemia remains a major cause of death in both developing as well as developed nations worldwide. Development of novel therapeutic approaches is perceived to be the best strategy to combat this disease. Availability of limited effective drugs with least side effects is the major hurdle in treating leukemia. Another major concern remains initiation and engagement of therapeutic strategies that may subvert or overcome drug-resistance. Deployment of plant-based molecules in therapeutic engagements is regarded to be the most apt approach to combat different forms of leukemia. Diterpenoids of natural origin have a broad range of therapeutic activities including anti-leukemic effect. In vitro and in vivo studies establish many diterpenoids from natural sources and their synthetic derivatives to have appreciable cytotoxic and apoptotic efficacies against a series of leukemic cells. This paper attempts to identify and describe diterpenoids with their plant sources and analyze the molecular mechanistic approaches underlying their effective apoptotic activities against leukemic cells studied till date. The present review article summarizes different categories of diterpenoids having various degrees of anti-leukemic activities and discusses the measures of overcoming the bio-availability issues of these natural molecules so that they can serve as extremely viable options in future leukemia therapy.
Keywords: Anti-cancer, apoptosis, cytotoxicity, diterpenoid, growth inhibition, leukemia.
Current Pharmaceutical Biotechnology
Title:Diterpenoids- Potential Chemopreventive and Chemotherapeutic Agents in Leukemia
Volume: 15 Issue: 2
Author(s): Swadesh Sarkar, Priya K. Gopal and Santanu Paul
Affiliation:
Keywords: Anti-cancer, apoptosis, cytotoxicity, diterpenoid, growth inhibition, leukemia.
Abstract: Leukemia remains a major cause of death in both developing as well as developed nations worldwide. Development of novel therapeutic approaches is perceived to be the best strategy to combat this disease. Availability of limited effective drugs with least side effects is the major hurdle in treating leukemia. Another major concern remains initiation and engagement of therapeutic strategies that may subvert or overcome drug-resistance. Deployment of plant-based molecules in therapeutic engagements is regarded to be the most apt approach to combat different forms of leukemia. Diterpenoids of natural origin have a broad range of therapeutic activities including anti-leukemic effect. In vitro and in vivo studies establish many diterpenoids from natural sources and their synthetic derivatives to have appreciable cytotoxic and apoptotic efficacies against a series of leukemic cells. This paper attempts to identify and describe diterpenoids with their plant sources and analyze the molecular mechanistic approaches underlying their effective apoptotic activities against leukemic cells studied till date. The present review article summarizes different categories of diterpenoids having various degrees of anti-leukemic activities and discusses the measures of overcoming the bio-availability issues of these natural molecules so that they can serve as extremely viable options in future leukemia therapy.
Export Options
About this article
Cite this article as:
Sarkar Swadesh, Gopal K. Priya and Paul Santanu, Diterpenoids- Potential Chemopreventive and Chemotherapeutic Agents in Leukemia, Current Pharmaceutical Biotechnology 2014; 15 (2) . https://dx.doi.org/10.2174/1389201015666140604121658
DOI https://dx.doi.org/10.2174/1389201015666140604121658 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Extracellular Matrix and Aberrant Signaling in Lung Carcinoma: Role of Fibronectin in the Control of Human Lung Carcinoma Cell Growth,Apoptosis and Resistance to Therapy
Current Signal Transduction Therapy The Important Roles of miR-205 in Normal Physiology, Cancers and as a Potential Therapeutic Target
Current Cancer Drug Targets Targeting HOTAIR induces mitochondria related apoptosis and inhibits tumor growth in head and neck squamous cell carcinoma in vitro and in vivo.
Current Molecular Medicine n-3 Polyunsaturated Fatty Acids as Signal Transduction Modulators and Therapeutical Agents in Cancer
Current Signal Transduction Therapy PET Imaging with [<sup>68</sup>Ga]NOTA-RGD for Prostate Cancer: A Comparative Study with [<sup>18</sup>F]Fluorodeoxyglucose and [<sup>18</sup>F]Fluoroethylcholine
Current Cancer Drug Targets MicroRNAs in Cancer: Small Molecules, Big Chances
Anti-Cancer Agents in Medicinal Chemistry Radiology of Oropharyngeal Cancer - Institutional Experience and Literature Review -
Current Cancer Therapy Reviews Targeting the Nucleus: An Overview of Auger-Electron Radionuclide Therapy
Current Drug Discovery Technologies Radiopharmaceuticals in Tumor Hypoxia Imaging: A Review Focused on Medicinal Chemistry Aspects
Anti-Cancer Agents in Medicinal Chemistry Targeting Epidermal Growth Factor Receptor in Solid Tumors: Critical Evaluation of the Biological Importance of Therapeutic Monoclonal Antibodies
Current Medicinal Chemistry Patent Selections:
Recent Patents on Anti-Cancer Drug Discovery Innovative Treatment Approach for Cancer-Related Cachexia
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Radiolabelled Peptides and Monoclonal Antibodies for Therapy Decision Making in Inflammatory Diseases
Current Pharmaceutical Design Amelioration of Cisplatin-induced Renal Inflammation by Recombinant Human Golimumab in Mice
Current Pharmaceutical Biotechnology Efficacy and Safety of the Combination of Docetaxel (Taxotere®) with Targeted Therapies in the Treatment of Solid Malignancies
Current Drug Targets Farnesylated Proteins as Anticancer Drug Targets: From Laboratory to the Clinic
Current Medicinal Chemistry - Anti-Cancer Agents Anticancer Antifolates: Current Status and Future Directions
Current Pharmaceutical Design Therapeutic Potential of Natural Compounds that Regulate the Activity of Protein Kinase C
Current Medicinal Chemistry Baicalein - An Intriguing Therapeutic Phytochemical in Pancreatic Cancer
Current Drug Targets The Effect of Lipoic Acid on Macro and Trace Metal Levels in Living Tissues Exposed to Oxidative Stress
Anti-Cancer Agents in Medicinal Chemistry