Abstract
This paper reviews puerperal metritis in the cow, particularly the complex and multi-factorial pathogenesis characterized by an altered cross-talk among infectious agents, endocrine and immune systems. Uterine infections impair fertility and is one of the main causes of economic losses in dairy production. The early postpartum is a period characterized by an increased exposition to infectious agents and the disruption of the metabolic homeostasis, leading to endocrine and immunologic disorders. Dysregulation of uterine defence mechanisms results in the development of metritis. Because there is a complex interaction between infectious, endocrine and immune factors during metritis, there is need to use safer and cheaper drugs which are able to strengthen the anti-infective actions of the routine therapies.
Keywords: Dairy cow, immunity, metritis, postpartum, uterine, uterus inflammatory diseases.
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:Immunological Aspects of Metritis in Dairy Cows: A Review
Volume: 14 Issue: 3
Author(s): Marianna Pantaleo, Annalisa Rizzo, Giovanni D'Onghia, Gianfranco D'Onghia, Maria Roncetti, Mariagrazia Piccinno, Maddalena Mutinati, Michele Roberto Terlizzi and Raffaele Luigi Sciorsci
Affiliation:
Keywords: Dairy cow, immunity, metritis, postpartum, uterine, uterus inflammatory diseases.
Abstract: This paper reviews puerperal metritis in the cow, particularly the complex and multi-factorial pathogenesis characterized by an altered cross-talk among infectious agents, endocrine and immune systems. Uterine infections impair fertility and is one of the main causes of economic losses in dairy production. The early postpartum is a period characterized by an increased exposition to infectious agents and the disruption of the metabolic homeostasis, leading to endocrine and immunologic disorders. Dysregulation of uterine defence mechanisms results in the development of metritis. Because there is a complex interaction between infectious, endocrine and immune factors during metritis, there is need to use safer and cheaper drugs which are able to strengthen the anti-infective actions of the routine therapies.
Export Options
About this article
Cite this article as:
Pantaleo Marianna, Rizzo Annalisa, D'Onghia Giovanni, D'Onghia Gianfranco, Roncetti Maria, Piccinno Mariagrazia, Mutinati Maddalena, Terlizzi Roberto Michele and Sciorsci Luigi Raffaele, Immunological Aspects of Metritis in Dairy Cows: A Review, Endocrine, Metabolic & Immune Disorders - Drug Targets 2014; 14 (3) . https://dx.doi.org/10.2174/1871530314666140527142346
DOI https://dx.doi.org/10.2174/1871530314666140527142346 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cardioprotective Potential of Iron Chelators and Prochelators
Current Medicinal Chemistry Stem Cells for Ocular Tissue Engineering and Regeneration
Current Topics in Medicinal Chemistry Relevance of the Deletion Polymorphisms of the Glutathione S-Transferases GSTT1 and GSTM1 in Pharmacology and Toxicology
Current Drug Metabolism Quassinoids: From Traditional Drugs to New Cancer Therapeutics
Current Medicinal Chemistry The Association between Tumor-associated Macrophages and Glioblastoma: A Potential Target for Therapy
Current Pharmaceutical Design Prosthetic Valve Endocarditis: Diagnostic Approach and Treatment Options
Cardiovascular & Hematological Disorders-Drug Targets Enhanced Hippocampal Neurogenesis in APP/Ps1 Mouse Model of Alzheimer's Disease After Implantation of VEGF-loaded PLGA Nanospheres
Current Alzheimer Research An Integrated In Silico Method to Discover Novel Rock1 Inhibitors: Multi- Complex-Based Pharmacophore, Molecular Dynamics Simulation and Hybrid Protocol Virtual Screening
Combinatorial Chemistry & High Throughput Screening Inflammation in Neurodegenerative Disorders: Friend or Foe?
Current Aging Science Asymmetric Dimethylarginine (ADMA): A Promising Biomarker for Cardiovascular Disease?
Current Topics in Medicinal Chemistry Recent Advance in the Research of Flavonoids as Anticancer Agents
Mini-Reviews in Medicinal Chemistry Respiratory Tract Manifestations of Rheumatic Diseases in Children
Current Respiratory Medicine Reviews Analogue of Melanotan II (MTII): A Novel Melanotropin with Superpotent Action on Frog Skin
Protein & Peptide Letters Anti-Inflammatory Iridoids of Botanical Origin
Current Medicinal Chemistry EMT Blockage Strategies: Targeting Akt Dependent Mechanisms for Breast Cancer Metastatic Behaviour Modulation
Current Gene Therapy Vitamin E - Occurrence, Biosynthesis by Plants and Functions in Human Nutrition
Mini-Reviews in Medicinal Chemistry AMPK as a New Attractive Therapeutic Target for Disease Prevention: The Role of Dietary Compounds AMPK and Disease Prevention
Current Drug Targets Side Effects of AAS Abuse: An Overview
Mini-Reviews in Medicinal Chemistry How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization
Mini-Reviews in Medicinal Chemistry Glucagon Like Peptides-1 Modulators as Newer Target for Diabetes
Current Drug Targets