Abstract
Asthma and obesity are two common disorders often associated in children and characterized by an inflammatory status. Growing evidences support a connection between obesity and asthma since weight reduction can improve asthmatic symptoms.
In this study, we have enrolled eighty children: 17 non asthmatics and non obese, 19 obese, 28 asthmatics-obese and, 16 asthmatics non-obese, respectively. In all participants, respiratory functional tests and body mass index (BMI) were calculated. Moreover, systemic inflammation of biomarkers such as T helper (h)1-type, Th2-type and T regulatory-type serum cytokines along with major adipokines was determined.
Data will show that the association between asthma and obesity leads to a predominant Th1-type response with an increase in pro-inflammatory cytokines. This inflammatory profile in asthmatics-obese children is sustained by elevated serum levels of leptin and visfatin, while adiponectin concentration is rather diminished.
Finally, levels of systemic inflammatory biomarkers positively correlate with the increase in BMI values in all population subgroups.
Keywords: Adiponectin, adipose tissue, asthma, children, cytokine, leptin, obesity, resistin, visfatin.
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:Characterization of the Immune Inflammatory Profile in Obese Asthmatic Children
Volume: 14 Issue: 3
Author(s): Thea Magrone, Maria Simone, Luigi Mappa, Riccardina Tesse, Paola Giordano, Maria Altamura and Irene Munno
Affiliation:
Keywords: Adiponectin, adipose tissue, asthma, children, cytokine, leptin, obesity, resistin, visfatin.
Abstract: Asthma and obesity are two common disorders often associated in children and characterized by an inflammatory status. Growing evidences support a connection between obesity and asthma since weight reduction can improve asthmatic symptoms.
In this study, we have enrolled eighty children: 17 non asthmatics and non obese, 19 obese, 28 asthmatics-obese and, 16 asthmatics non-obese, respectively. In all participants, respiratory functional tests and body mass index (BMI) were calculated. Moreover, systemic inflammation of biomarkers such as T helper (h)1-type, Th2-type and T regulatory-type serum cytokines along with major adipokines was determined.
Data will show that the association between asthma and obesity leads to a predominant Th1-type response with an increase in pro-inflammatory cytokines. This inflammatory profile in asthmatics-obese children is sustained by elevated serum levels of leptin and visfatin, while adiponectin concentration is rather diminished.
Finally, levels of systemic inflammatory biomarkers positively correlate with the increase in BMI values in all population subgroups.
Export Options
About this article
Cite this article as:
Magrone Thea, Simone Maria, Mappa Luigi, Tesse Riccardina, Giordano Paola, Altamura Maria and Munno Irene, Characterization of the Immune Inflammatory Profile in Obese Asthmatic Children, Endocrine, Metabolic & Immune Disorders - Drug Targets 2014; 14 (3) . https://dx.doi.org/10.2174/1871530314666140526095211
DOI https://dx.doi.org/10.2174/1871530314666140526095211 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Oxidative Stress in Allergic and Irritant Dermatitis: From Basic Research to Clinical Management
Recent Patents on Inflammation & Allergy Drug Discovery A Short Exploration of Selected Sensitive CYP3A4 Substrates (Probe Drug)
Drug Metabolism Letters Recent Progress in Rational Drug Design of Neuraminidase Inhibitors
Current Medicinal Chemistry In-silico Inhibitory Study of cFos-cJun Complex by T-5224 Based Small Molecule Analogs
Letters in Drug Design & Discovery Coumarins as Antioxidants
Current Medicinal Chemistry Novel Pharmacologic Approaches to the Management of Sepsis: Targeting the Host Inflammatory Response
Recent Patents on Inflammation & Allergy Drug Discovery SARS-CoV-2 Transmission Among Healthcare Workers in Iran: An Urgent Need for Early Identification and Management
Infectious Disorders - Drug Targets Chinese Herbal Medicine for Hyperlipidaemia: A Review Based on Data Mining from 1990 to 2016
Current Vascular Pharmacology Biological Predictors of Aging and Potential of FTIR to Study Age-related Diseases and Aging Metabolic Fingerprint
Current Metabolomics Nitric Oxide Signaling and the Cross Talk with Prostanoids Pathways in Vascular System
Medicinal Chemistry Endogenous Cardioprotective Agents: Role in Pre and Postconditioning
Current Drug Targets Subject Index
Current Drug Targets - Inflammation & Allergy Editorial [Hot topic: Sleep Abnormalities in Pulmonary Disease (Guest Editor: Shyamsunder Subramanian)]
Current Respiratory Medicine Reviews Growing up in the Web of Social Networking: Adolescent Development and Social Media
Adolescent Psychiatry Pyridines and Imidazopyridines with Medicinal Significance
Current Topics in Medicinal Chemistry Synthesis of pyridyl benzimidazoles encompassing 4-thiazolidinone derivatives as potential antimicrobial agents
Letters in Drug Design & Discovery Chiral Kinase Inhibitors
Current Topics in Medicinal Chemistry A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections
Current Pharmaceutical Design Poly(ADP-ribose)polymerase Inhibition - Where Now?
Current Medicinal Chemistry The Cough Receptor TRPV1 Agonists 15(S)-HETE and LTB4 in the Cough Response to Hypertonicity
Inflammation & Allergy - Drug Targets (Discontinued)