Abstract
Glycogen synthase kinase 3β (GSK-3β) is implicated in diverse cellular processes such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3β activity contributes to neuronal death and pathogenesis of ischemic stroke. Considering predominant roles of GSK-3β in neuronal apoptosis, modulation of this protein kinase is a reliable strategy for ischemic neuroprotection. In this review, we survey and synthesize the current knowledge about the role of GSK-3β in neuroprotection following the ischemic stroke.
Keywords: Apoptosis, brain, GSK-3β, hypoxia, ischemic stroke, neuronal death.
Current Neurovascular Research
Title:Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death
Volume: 11 Issue: 3
Author(s): Pradeep Hanumanthappa, Asha Densi and Rajanikant Golgodu Krishnamurthy
Affiliation:
Keywords: Apoptosis, brain, GSK-3β, hypoxia, ischemic stroke, neuronal death.
Abstract: Glycogen synthase kinase 3β (GSK-3β) is implicated in diverse cellular processes such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3β activity contributes to neuronal death and pathogenesis of ischemic stroke. Considering predominant roles of GSK-3β in neuronal apoptosis, modulation of this protein kinase is a reliable strategy for ischemic neuroprotection. In this review, we survey and synthesize the current knowledge about the role of GSK-3β in neuroprotection following the ischemic stroke.
Export Options
About this article
Cite this article as:
Hanumanthappa Pradeep, Densi Asha and Krishnamurthy Golgodu Rajanikant, Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death, Current Neurovascular Research 2014; 11 (3) . https://dx.doi.org/10.2174/1567202611666140520151002
DOI https://dx.doi.org/10.2174/1567202611666140520151002 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Immunophilins and Cardiovascular Complications
Current Medicinal Chemistry Radiopharmaceuticals for Oncology Drug Development: A Pharmaceutical Industry Perspective
Current Pharmaceutical Design Gender Differences in the Clinical Presentation of Heart Disease
Current Pharmaceutical Design Oxidative Stress in the Early Stage of Psychosis
Current Topics in Medicinal Chemistry Inflammatory Cytokines and Cardiovascular Disease
Current Drug Targets - Inflammation & Allergy Controlling Apoptosis by Inhibition of Caspases
Current Medicinal Chemistry Before and After Preeclampsia: What Biomarkers are there?
Current Women`s Health Reviews Role of Nitric Oxide in Ischemia and Reperfusion Injury
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Pharmacological Prevention of Peri-, and Post-Procedural Myocardial Injury in Percutaneous Coronary Intervention
Current Cardiology Reviews Exploiting Anti-Inflammation Effects of Flavonoids in Chronic Inflammatory Diseases
Current Pharmaceutical Design Sex Hormones, Metabolic Syndrome and Kidney
Current Topics in Medicinal Chemistry Hydrophilic Carotenoid Amphiphiles: Methods of Synthesis and Biological Applications
Mini-Reviews in Medicinal Chemistry The Central Role of Angiotensin I-Converting Enzyme in Vertebrate Pathophysiology
Current Topics in Medicinal Chemistry Cardioprotection Against Ischemia/Reperfusion Injury and Chromogranin ADerived Peptides
Current Medicinal Chemistry Thienopyridines in Percutaneous Coronary Interventions: Standard Procedures and High Risk Subsets
Current Pharmaceutical Design Emerging Therapy for Diabetic Neuropathy: Cell Therapy Targeting Vessels and Nerves
Endocrine, Metabolic & Immune Disorders - Drug Targets Serum Amyloid A and Its Potential Physiological / Pathological Functions - an Overview of Patents
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Radionuclide Imaging in Patients with Ischemic Heart Failure
Current Medical Imaging The FDG-PET Revolution of Medical Imaging – Four Decades and Beyond
Current Molecular Imaging (Discontinued) The Gut and Intestinal Bacteria in Chronic Heart Failure
Current Drug Metabolism