Abstract
Glycogen synthase kinase 3β (GSK-3β) is implicated in diverse cellular processes such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3β activity contributes to neuronal death and pathogenesis of ischemic stroke. Considering predominant roles of GSK-3β in neuronal apoptosis, modulation of this protein kinase is a reliable strategy for ischemic neuroprotection. In this review, we survey and synthesize the current knowledge about the role of GSK-3β in neuroprotection following the ischemic stroke.
Keywords: Apoptosis, brain, GSK-3β, hypoxia, ischemic stroke, neuronal death.
Current Neurovascular Research
Title:Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death
Volume: 11 Issue: 3
Author(s): Pradeep Hanumanthappa, Asha Densi and Rajanikant Golgodu Krishnamurthy
Affiliation:
Keywords: Apoptosis, brain, GSK-3β, hypoxia, ischemic stroke, neuronal death.
Abstract: Glycogen synthase kinase 3β (GSK-3β) is implicated in diverse cellular processes such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3β activity contributes to neuronal death and pathogenesis of ischemic stroke. Considering predominant roles of GSK-3β in neuronal apoptosis, modulation of this protein kinase is a reliable strategy for ischemic neuroprotection. In this review, we survey and synthesize the current knowledge about the role of GSK-3β in neuroprotection following the ischemic stroke.
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Cite this article as:
Hanumanthappa Pradeep, Densi Asha and Krishnamurthy Golgodu Rajanikant, Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death, Current Neurovascular Research 2014; 11 (3) . https://dx.doi.org/10.2174/1567202611666140520151002
DOI https://dx.doi.org/10.2174/1567202611666140520151002 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
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