MicroRNA-Mediated Cancer Metastasis Regulation via Heterotypic Signals in the Microenvironment

Title:MicroRNA-Mediated Cancer Metastasis Regulation via Heterotypic Signals in the Microenvironment

Volume: 15 Issue: 5

Author(s): Haizhong Ma, Chunli Liang, Guangxue Wang, Sujuan Jia, Qian Zhao, Zhendong Xiang, Yuan Li, William C. Cho, Richard G. Pestell, Li Liang and Zuoren Yu

Affiliation:

Keywords: Cancer, exosome, metastasis, microenvironment, miRNA.

Abstract: MicroRNAs (miRNAs) are thought to regulate tumor progression and metastasis via direct interaction with target genes within cells. Emerging evidence has demonstrated the secretion of miRNAs into environment via cancer cell exosomes, called “exosomal shuttle small RNA”. Microenvironmental miRNAs are important mediators of cell-to-cell communication, and they play important roles in regulating cancer metastasis. RNA analysis indicates enrichment of the miRNA population in cell-culturing medium. miRNA-conditioned medium is able to mediate the function of miRNAs in regulating cancer cell migration and invasion. Here we combine our recent work with literature discussing multiple mechanisms through which exosomal miRNAs regulate cancer cell migration, invasion and metastasis. We summarize a heterotypic signaling pathway by which miRNA regulates the cellular secretion and tumor microenvironment in control of breast cancer cell migration and invasion. In conclusion, exosomal miRNAs are able to regulate cancer metastasis via heterotypic signals in the microenvironment.

Cite this article as:

Ma Haizhong, Liang Chunli, Wang Guangxue, Jia Sujuan, Zhao Qian, Xiang Zhendong, Li Yuan, Cho C. William, Pestell G. Richard, Liang Li and Yu Zuoren, MicroRNA-Mediated Cancer Metastasis Regulation via Heterotypic Signals in the Microenvironment, Current Pharmaceutical Biotechnology 2014; 15 (5) . https://dx.doi.org/10.2174/1389201015666140516112042