Generic placeholder image

Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Macrolactins: Antitumor Antibiotics as Marine Drug Lead

Author(s): Tingting Wang, Shan He, Xiaojun Yan and Peng Zhu

Volume 18, Issue 7, 2014

Page: [804 - 811] Pages: 8

DOI: 10.2174/138527281807140515144549

Price: $65

Abstract

Macrolactins are secondary metabolites mainly from marine microorganisms bearing a unique 24-membered lactone core structure. Since their first occurrence in 1989, they have attracted considerable attention from natural product chemists, organic chemists, and pharmacologists due to their chemical complexity, potent antimicrobial and antitumor activities. Some of them are serving as lead compounds for drug discovery. Although a number of synthetic approaches have been developed, sample supply remains a big issue which precludes further investigation of pharmacological application and mechanisms of action. This review summarizes current knowledge about macrolactins including their chemical diversity, biological activities, synthetic studies, and efficient preparation.

Keywords: Antibiotic, antitumor, chemical diversity, efficient preparation, macrolactins, synthesis.

Graphical Abstract

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy