Synthesis of 3-substituted Coumarins: An Efficient Green Approach Using L-proline as Catalyst in Triethanolamine Medium

Title:Synthesis of 3-substituted Coumarins: An Efficient Green Approach Using L-proline as Catalyst in Triethanolamine Medium

Volume: 11 Issue: 8

Author(s): Devulapally Srikrishna, Syed Tasqeeruddin and Pramod Kumar Dubey

Affiliation:

Keywords: Salicylaldehydes, active methylene compounds, L-proline, triethanolamine, coumarins, Knoevenagel condensation.

Abstract: 3-Substituted coumarins were synthesized very efficiently, using Knoevenagel method from salicylaldehydes 1 and active methylene compounds 2 under green conditions. The effect of catalyst and solvent on this condensation was studied. L-proline was found to be the best catalyst and triethanolamine the best reaction medium for this reaction.

Cite this article as:

Srikrishna Devulapally, Tasqeeruddin Syed and Kumar Dubey Pramod, Synthesis of 3-substituted Coumarins: An Efficient Green Approach Using L-proline as Catalyst in Triethanolamine Medium, Letters in Organic Chemistry 2014; 11 (8) . https://dx.doi.org/10.2174/1570178611666140512215136