Functionalization of Tetracycline and Evaluation of Its Antibacterial Activity Including Against Resistant Bacteria

Priyanka      Dogra; Ghanshyam   S.   Chauhan

Abstract

Ever growing resistance of pathogenic bacteria against the existing antibiotics has forced researchers to look for new methods and techniques to design effective antimicrobial agents. In the present study a new tetracycline-based antimicrobial polymer (AMP) was synthesized from tetracycline and methacrylic acid (MAAc) using lipase as catalyst. The AMP, thus obtained, was transformed into nanoparticles via an emulsion method. The AMP and its nano-form were characterized by FTIR, NMR, XRD, SEM and EDAX. The antibacterial activity of the AMP was studied against both resistant (-) [P. aeruginosa] and susceptible (+) [S. aureus] bacteria. The synthesized AMP, including its nanoform, was observed to be more potent and efficient antimicrobial agent than the precursor tetracycline.

Keywords: Acryloylation, antimicrobial polymers, lipase, resistant bacteria, tetracycline.

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Medicinal Chemistry

Title:Functionalization of Tetracycline and Evaluation of Its Antibacterial Activity Including Against Resistant Bacteria

Volume: 11 Issue: 1

Author(s): Priyanka Dogra and Ghanshyam S. Chauhan

Affiliation:

Keywords: Acryloylation, antimicrobial polymers, lipase, resistant bacteria, tetracycline.

Abstract: Ever growing resistance of pathogenic bacteria against the existing antibiotics has forced researchers to look for new methods and techniques to design effective antimicrobial agents. In the present study a new tetracycline-based antimicrobial polymer (AMP) was synthesized from tetracycline and methacrylic acid (MAAc) using lipase as catalyst. The AMP, thus obtained, was transformed into nanoparticles via an emulsion method. The AMP and its nano-form were characterized by FTIR, NMR, XRD, SEM and EDAX. The antibacterial activity of the AMP was studied against both resistant (-) [P. aeruginosa] and susceptible (+) [S. aureus] bacteria. The synthesized AMP, including its nanoform, was observed to be more potent and efficient antimicrobial agent than the precursor tetracycline.

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Dogra Priyanka and Chauhan S. Ghanshyam, Functionalization of Tetracycline and Evaluation of Its Antibacterial Activity Including Against Resistant Bacteria, Medicinal Chemistry 2015; 11 (1) . https://dx.doi.org/10.2174/1573406410666140507094435

DOI https://dx.doi.org/10.2174/1573406410666140507094435	Print ISSN 1573-4064
Publisher Name Bentham Science Publisher	Online ISSN 1875-6638

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