Abstract
With the recent emergence of novel technologies, the field of biomarker discovery has been the subject of intense research and activity. Major advances in cancer control will be greatly aided by early detection for the diagnosis and treatment of cancer in its pre-invasive state. Cancer being a diverse disease involves alterations in three classes of genes viz. (proto) oncogenes, tumour suppressor genes and DNA repair genes offering a wide variety of opportunities for the development of biomarkers. The emergence of innovative technologies in genomics, proteomics, metabolomics and imaging allows researchers to facilitate inclusive analysis of cancer cells. These approaches have already demonstrated its power to discriminate cancer cells from normal cells and to identify specific genetic elements involved in cancer progression. Cancer evolves via manifold pathways and is a culmination of a variety of genetic, molecular and clinical events. In the past few years, several reports have led to identification of novel cancer signatures via high throughput biology. Current review gives an overview of the bioinformatics tools, cancer database and available software package tools and further summarizes about different strategies involved in Omics research (genomics, proteomics, metabolomics) for the development of cancer biomarkers. We also discuss about the current and emerging biomarkers in breast cancer with fundamental insight into different markers used in breast cancer detection. In addition, we focus upon the systematic integration of various omic data for accelerating cancer biomarker discovery with evidence based cancer management. The above strategies may lead to significant improvement in cancer screening, prognosis and management of therapeutic response in cancer patients.
Keywords: Biomarkers, cancer, genomics, imaging, metabolomics, proteomics, diagnostic markers, validation.
Current Cancer Drug Targets
Title:Prognostic and Predictive Biomarkers in Cancer
Volume: 14 Issue: 5
Author(s): Meera Nair, Sardul Singh Sandhu and Anil K. Sharma
Affiliation:
Keywords: Biomarkers, cancer, genomics, imaging, metabolomics, proteomics, diagnostic markers, validation.
Abstract: With the recent emergence of novel technologies, the field of biomarker discovery has been the subject of intense research and activity. Major advances in cancer control will be greatly aided by early detection for the diagnosis and treatment of cancer in its pre-invasive state. Cancer being a diverse disease involves alterations in three classes of genes viz. (proto) oncogenes, tumour suppressor genes and DNA repair genes offering a wide variety of opportunities for the development of biomarkers. The emergence of innovative technologies in genomics, proteomics, metabolomics and imaging allows researchers to facilitate inclusive analysis of cancer cells. These approaches have already demonstrated its power to discriminate cancer cells from normal cells and to identify specific genetic elements involved in cancer progression. Cancer evolves via manifold pathways and is a culmination of a variety of genetic, molecular and clinical events. In the past few years, several reports have led to identification of novel cancer signatures via high throughput biology. Current review gives an overview of the bioinformatics tools, cancer database and available software package tools and further summarizes about different strategies involved in Omics research (genomics, proteomics, metabolomics) for the development of cancer biomarkers. We also discuss about the current and emerging biomarkers in breast cancer with fundamental insight into different markers used in breast cancer detection. In addition, we focus upon the systematic integration of various omic data for accelerating cancer biomarker discovery with evidence based cancer management. The above strategies may lead to significant improvement in cancer screening, prognosis and management of therapeutic response in cancer patients.
Export Options
About this article
Cite this article as:
Nair Meera, Sandhu Singh Sardul and Sharma K. Anil, Prognostic and Predictive Biomarkers in Cancer, Current Cancer Drug Targets 2014; 14 (5) . https://dx.doi.org/10.2174/1568009614666140506111118
DOI https://dx.doi.org/10.2174/1568009614666140506111118 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
Call for Papers in Thematic Issues
Advances in Cancer Biomarkers and Potential Drug Targets: From Diagnosis to Therapy
Cancer biomarkers play a crucial role in the diagnosis, prognosis, and treatment of cancer. They provide valuable information for cancer detection, risk assessment, treatment selection, and monitoring response to therapy. With advancements in molecular biology and high-throughput technologies, there has been an increasing interest in identifying and characterizing cancer biomarkers ...read more
Novel Therapeutic Approaches to Target Drug Resistant Tumors
With the development of disciplines such as chemical biology and molecular biology, the genes or proteins closely related to tumor occurrence and development have gradually become clear. Targeted therapies targeting these genes or proteins provide more effective methods for tumor treatment. Tumor targeted drugs generally only act on specific targets ...read more
ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process to explore and investigate the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment
Immune system protects host against malignant tumors through effector cells and molecules. Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses cancer progression. Chronic inflammation facilitates cancer progression and treatment resistance, whereas induction of acute inflammatory reactions often lead to anti-cancer immune responses. ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Drug Transporters in Chemotherapy Induced Peripheral Neurotoxicity:Current Knowledge and Clinical Implications
Current Medicinal Chemistry The Ligand Binding Region of the Sigma-1 Receptor: Studies Utilizing Photoaffinity Probes, Sphingosine and N-Alkylamines
Current Pharmaceutical Design Histone Deacetylase Inhibitors: An Attractive Strategy for Cancer Therapy
Current Medicinal Chemistry Aryl Hydrocarbon Receptor: Its Regulation and Roles in Transformation and Tumorigenesis
Current Drug Targets Preclinical and Clinical Efficacy of the Bisphosphonate Ibandronate in Cancer Treatment
Current Clinical Pharmacology Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry
Medicinal Chemistry Synthesis and Preliminary Biological Evaluation of New Heterocyclic Carboxamide Models
Letters in Drug Design & Discovery The Multidrug Resistance Mechanisms and their Interactions with the Radiopharmaceutical Probes Used for an In Vivo Detection
Current Drug Metabolism The Role of the Gastrointestinal Microbiota in Colorectal Cancer
Current Pharmaceutical Design Significance of Various Experimental Models and Assay Techniques in Cancer Diagnosis
Mini-Reviews in Medicinal Chemistry Rationalizing the Study of Plants for the Treatment of Oral Pain
Current Chemical Biology γ-Secretase Substrates and their Implications for Drug Development in Alzheimer's Disease
Current Topics in Medicinal Chemistry Reversal of Tumor Induced Dendritic Cell Paralysis: A Treatment Regimen Against Cancer
Current Immunology Reviews (Discontinued) Thyroid Hormone Levels in the Prefrontal Cortex of Post-Mortem Brains of Alzheimers Disease Patients
Current Aging Science Autoantibody Profiles as Biomarkers for Response to Therapy and Early Detection of Cancer
Current Cancer Therapy Reviews Enteric Coated Guar Gum Microspheres of Ornidazole for Colonic Delivery
Current Nanoscience MR Spectroscopy in Metabolic Profiling Studies of Stem Cells
Current Medical Imaging Atopic Dermatitis and Cytokines: Recent Patents in Immunoregulatory and Therapeutic Implications of Cytokines in Atopic Dermatitis - Part I: Cytokines in Atopic Dermatitis
Recent Patents on Inflammation & Allergy Drug Discovery Regulation of Glycolytic and Mitochondrial Metabolism by Ras
Current Pharmaceutical Biotechnology Fibroblast Growth Factor Receptor (FGFR): A New Target for Non-small Cell Lung Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry