Abstract
Quinolines as one of the most important classes of heterocyclic compounds are widely present as key structural motifs in many natural products, particularly in alkaloids and numerous bioactive drugs. Various name reactions for the syntheses of quinolines such as Skraup, Camps, Combes, Conrad-Lympach, Knorr, Gould-Jacobs, Povarov, Doebner and Doebner-von Miller, Pfitzinger and Niementowski, and Friedländer have already been discovered and extensively developed and modified. This review covers the most recent applications of Doebner and Doebner-von Miller reactions in organic syntheses. In addition the developments of the Knoevenagel- Doebner reaction in the synthesis of α,β-unsaturated carboxylic acids were demonstrated. In this paper we provide extensive compilation of the development of the Doebner reaction and variations for the synthesis of quinolines published from 2006 to 2013.
Keywords: Doebner reaction, doebner-von miller, heterocyclic syntheses, Knoevenagel reaction, quinolines.
Current Organic Synthesis
Title:Recent Applications of Doebner, Doebner-von Miller and Knoevenagel-Doebner Reactions in Organic Syntheses
Volume: 11 Issue: 5
Author(s): Majid M. Heravi, Shima Asadi and Fatemeh Azarakhshi
Affiliation:
Keywords: Doebner reaction, doebner-von miller, heterocyclic syntheses, Knoevenagel reaction, quinolines.
Abstract: Quinolines as one of the most important classes of heterocyclic compounds are widely present as key structural motifs in many natural products, particularly in alkaloids and numerous bioactive drugs. Various name reactions for the syntheses of quinolines such as Skraup, Camps, Combes, Conrad-Lympach, Knorr, Gould-Jacobs, Povarov, Doebner and Doebner-von Miller, Pfitzinger and Niementowski, and Friedländer have already been discovered and extensively developed and modified. This review covers the most recent applications of Doebner and Doebner-von Miller reactions in organic syntheses. In addition the developments of the Knoevenagel- Doebner reaction in the synthesis of α,β-unsaturated carboxylic acids were demonstrated. In this paper we provide extensive compilation of the development of the Doebner reaction and variations for the synthesis of quinolines published from 2006 to 2013.
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Cite this article as:
Heravi M. Majid, Asadi Shima and Azarakhshi Fatemeh, Recent Applications of Doebner, Doebner-von Miller and Knoevenagel-Doebner Reactions in Organic Syntheses, Current Organic Synthesis 2014; 11 (5) . https://dx.doi.org/10.2174/1570179411666140426003616
DOI https://dx.doi.org/10.2174/1570179411666140426003616 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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