Aqua Mediated One-Pot Synthesis of 2-Amino-tetrahydrobenzo[b]pyran Derivatives Catalyzed by Mg(NO₃)₂•6H₂O

Title:Aqua Mediated One-Pot Synthesis of 2-Amino-tetrahydrobenzo[b]pyran Derivatives Catalyzed by Mg(NO₃)₂•6H₂O

Volume: 11 Issue: 7

Author(s): Boudjemaa Boumoud, Amina Debbache, Taoues Boumoud, Raouf Boulcina and Abdelmadjid Debache

Affiliation:

Keywords: Mg(NO₃)₂•6H₂O, multi-component reaction, 4H-benzo[b]pyran, active methylene nitrile, aqua mediated, dimedone.

Abstract: We describe herein a clean and efficient one-pot synthesis of 4H-benzo[b]pyran derivatives using dimedone, active methylene nitriles and aryl aldehyde via Knoevenagel condensation followed by Michael addition in the presence of Mg(NO₃)₂•6H₂O as catalyst and water as a green solvent. The advantages of this method lie in its simplicity, low catalyst loading, cost effectiveness and easy handling. The present method also allows us to synthesize highly functionalized tetrahydrobenzo[b]pyran derivatives from simple and readily available starting materials.

Cite this article as:

Boumoud Boudjemaa, Debbache Amina, Boumoud Taoues, Boulcina Raouf and Debache Abdelmadjid, Aqua Mediated One-Pot Synthesis of 2-Amino-tetrahydrobenzo[b]pyran Derivatives Catalyzed by Mg(NO₃)₂•6H₂O, Letters in Organic Chemistry 2014; 11 (7) . https://dx.doi.org/10.2174/1570178611666140401221534