Abstract
In 2006, Takahashi and Yamanaka first established induced pluripotent stem cells (iPScs). Since then, numerous improvements have been made in the fields of stem cell research, drug research, modelling of diseases, and the treatment of degenerative diseases. Recently, there has been increasing research involving small molecules for evaluating the efficiency of iPSc generation and reducing the risks of heredity as well as oncogenous problems. However, the molecular mechanisms of iPScs remain to be further explored, to meet the demands of practical applications. With a better understanding of degenerative diseases, more complex treatment strategies for novel regenerative medicine are anticipated, and iPSc technology offers an available pathway. This review focuses on the development and application of iPScs.
Keywords: Application, degenerative disease, differentiation, epigenetic regulation, induced pluripotent stem cells, regenerative medicine.
Current Stem Cell Research & Therapy
Title:Development Course and an Application Strategy for Induced Pluripotent Stem Cells in Regenerative Medicine
Volume: 9 Issue: 3
Author(s): Yuanzhi Xu, Jing Wang, Runyi Mao, Xiaoshan Tang, Renhuan Huang, Raorao Wang and Yunfeng Lin
Affiliation:
Keywords: Application, degenerative disease, differentiation, epigenetic regulation, induced pluripotent stem cells, regenerative medicine.
Abstract: In 2006, Takahashi and Yamanaka first established induced pluripotent stem cells (iPScs). Since then, numerous improvements have been made in the fields of stem cell research, drug research, modelling of diseases, and the treatment of degenerative diseases. Recently, there has been increasing research involving small molecules for evaluating the efficiency of iPSc generation and reducing the risks of heredity as well as oncogenous problems. However, the molecular mechanisms of iPScs remain to be further explored, to meet the demands of practical applications. With a better understanding of degenerative diseases, more complex treatment strategies for novel regenerative medicine are anticipated, and iPSc technology offers an available pathway. This review focuses on the development and application of iPScs.
Export Options
About this article
Cite this article as:
Xu Yuanzhi, Wang Jing, Mao Runyi, Tang Xiaoshan, Huang Renhuan, Wang Raorao and Lin Yunfeng, Development Course and an Application Strategy for Induced Pluripotent Stem Cells in Regenerative Medicine, Current Stem Cell Research & Therapy 2014; 9 (3) . https://dx.doi.org/10.2174/1574888X09666140213202227
DOI https://dx.doi.org/10.2174/1574888X09666140213202227 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
ACE and ACE2 in Inflammation: A Tale of Two Enzymes
Inflammation & Allergy - Drug Targets (Discontinued) The Role of Beta-Blocker in Heart Failure in Adults with Congenital Heart Disease
Reviews on Recent Clinical Trials The Role of Dronedarone in the Treatment of Atrial Fibrillation/Flutter in the Aftermath of PALLAS
Current Cardiology Reviews Wharton's Jelly Mesenchymal Stem Cell Response on Chitosan-graft-poly (ε-caprolactone) Copolymer for Myocardium Tissue Engineering
Current Pharmaceutical Design Obstructive Sleep Apnea Syndrome: An Emerging Risk Factor for Dementia
CNS & Neurological Disorders - Drug Targets Neurologic and Cardiovascular Complications in Pediatric Life Threatening Imipramine Poisoning
Current Drug Safety Cytochrome P450 2C8 and Drug Metabolism
Current Topics in Medicinal Chemistry The Two fACEs of the Tissue Renin-Angiotensin Systems: Implication in Cardiovascular Diseases
Current Pharmaceutical Design MicroRNAs in Aortic Disease
Current Topics in Medicinal Chemistry Clinical Management of Arrhythmogenic Right Ventricular Cardiomyopathy: An Update
Current Pharmaceutical Design Electrocardiogram in Andersen-Tawil Syndrome. New Electrocardiographic Criteria for Diagnosis of Type-1 Andersen-Tawil Syndrome
Current Cardiology Reviews Pharmacogenomics: A Tool to Prevent and Cure Coronary Heart Disease
Current Pharmaceutical Design Approaches and Recent Trends in Gene Delivery for Treatment of Atherosclerosis
Recent Patents on Drug Delivery & Formulation Novel Inflammatory Biomarkers in Cardiovascular Therapeutics
Current Medicinal Chemistry Safety and Complications Reporting Update on the Re-Implantation of Culture-Expanded Mesenchymal Stem Cells Using Autologous Platelet Lysate Technique
Current Stem Cell Research & Therapy Marfan Syndrome and Related Heritable Thoracic Aortic Aneurysms and Dissections
Current Pharmaceutical Design Newer Insights in Personalized and Evidence Based Medicine- the Role of MicroRNAs
Current Pharmacogenomics and Personalized Medicine Pulmonary Hypertension secondary to Left Heart Disease
Current Vascular Pharmacology Calcium Store Stability as an Antiarrhythmic Endpoint
Current Pharmaceutical Design Recent Advances in Exercise Testing
Current Cardiology Reviews