Abstract
The use of polymers in different fields of modern medicine has generated significant advances in tissue engineering, diagnostic and therapeutic strategies. Polymers have been used to control the rate of drug release, prevent toxicity, protect drugs from degradation before delivery, target drugs to the site of action, improve absorption, bioavailability and therapeutic efficacy. Although synthetic polymers allow producing tailor-made materials, however natural polymers exhibit the advantages of excellent biodegradability, biocompatibility, cost-effectiveness and environmental friendliness. This review presents the current status of research and clinical applications of natural polymers as drug delivery systems for different administration routes.
Keywords: Natural polymers, proteins, polysaccharides, drug delivery, mucosal delivery, enteral delivery, central nervous system delivery.
Current Organic Chemistry
Title:Biomedical Applications of Natural Polymers for Drug Delivery
Volume: 18 Issue: 2
Author(s): Mariana Carmen Chifiriuc, Alexandru Mihai Grumezescu, Valentina Grumezescu, Eugenia Bezirtzoglou, Veronica Lazar and Alexandra Bolocan
Affiliation:
Keywords: Natural polymers, proteins, polysaccharides, drug delivery, mucosal delivery, enteral delivery, central nervous system delivery.
Abstract: The use of polymers in different fields of modern medicine has generated significant advances in tissue engineering, diagnostic and therapeutic strategies. Polymers have been used to control the rate of drug release, prevent toxicity, protect drugs from degradation before delivery, target drugs to the site of action, improve absorption, bioavailability and therapeutic efficacy. Although synthetic polymers allow producing tailor-made materials, however natural polymers exhibit the advantages of excellent biodegradability, biocompatibility, cost-effectiveness and environmental friendliness. This review presents the current status of research and clinical applications of natural polymers as drug delivery systems for different administration routes.
Export Options
About this article
Cite this article as:
Chifiriuc Carmen Mariana, Grumezescu Mihai Alexandru, Grumezescu Valentina, Bezirtzoglou Eugenia, Lazar Veronica and Bolocan Alexandra, Biomedical Applications of Natural Polymers for Drug Delivery, Current Organic Chemistry 2014; 18 (2) . https://dx.doi.org/10.2174/138527281802140129104525
DOI https://dx.doi.org/10.2174/138527281802140129104525 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Co-Metabolism within the Gut-Brain Metabolic Interaction: Potential Targets for Drug Treatment and Design
CNS & Neurological Disorders - Drug Targets Specific and Sensitive RP-HPLC Method Development and Validation for the Determination of Aripiprazole: Application in Preformulation Screening of Nanoemulsion
Current Nanomedicine RNAi Screening Identifies TAK1 as a Potential Target for the Enhanced Efficacy of Topoisomerase Inhibitors
Current Cancer Drug Targets Therapeutic Targeting of CPT-11 Induced Diarrhea: A Case for Prophylaxis
Current Drug Targets Developments in the Application of 1,2,3-Triazoles in Cancer Treatment
Recent Patents on Anti-Cancer Drug Discovery Brain Tumour Stem Cells: Implications for Cancer Therapy and Regenerative Medicine
Current Stem Cell Research & Therapy Gut Inflammation: Current Update on Pathophysiology, Molecular Mechanism and Pharmacological Treatment Modalities
Current Pharmaceutical Design Immune Function in Pregnant Women with Affective Disorders
Current Psychiatry Reviews Inhibitors of Chronically Active Ras: Potential for Treatment of Human Malignancies
Recent Patents on Anti-Cancer Drug Discovery CDK Inhibitors Induce Mitochondria-mediated Apoptosis Through the Activation of Polyamine Catabolic Pathway in LNCaP, DU145 and PC3 Prostate Cancer Cells
Current Pharmaceutical Design Predicting the Metabolic Pathways of Small Molecules Based on Their Physicochemical Properties
Protein & Peptide Letters Inhibition of c-Met with the Specific Small Molecule Tyrosine Kinase Inhibitor SU11274 Decreases Growth and Metastasis Formation of Experimental Human Melanoma
Current Cancer Drug Targets The Changing Role of Radiation in the Post-TME ERA of Rectal Cancer
Current Cancer Therapy Reviews FLIM-FRET for Cancer Applications
Current Molecular Imaging (Discontinued) Advances in Nuclear Oncology: Microspheres for Internal Radionuclide Therapy of Liver Tumours
Current Medicinal Chemistry MicroRNAs for Diagnosis and Treatment of Colorectal Cancer
Endocrine, Metabolic & Immune Disorders - Drug Targets Use of Transgenic Mice as Models for Prostate Cancer Chemoprevention
Current Molecular Medicine Cetuximab/Irinotecan-Chemotherapy in KRAS Wild-type Pretreated Metastatic Colorectal Cancer: A Pooled Analysis and Review of Literature.
Reviews on Recent Clinical Trials MicroRNAs Regulate the Epithelial to Mesenchymal Transition (EMT) in Cancer Progression
MicroRNA Paris Saponin VII Induces Apoptosis and Cell Cycle Arrest in Erythroleukemia Cells by a Mitochondrial Membrane Signaling Pathway
Anti-Cancer Agents in Medicinal Chemistry