Abstract
Cardioprotective effect of resveratrol and resveratroloside was determined in ischemia-reperfusion experiments on rats. It was found that single intraperitoneal administration of any compound (10 mg/kg) followed by 30-min ischemia and 120-min reperfusion resulted in statistically significant decrease of myocardial infarct area (55.0±4.0% for control group; 40.7±4.4% for the group 1 received resveratrol; 41.6±4.8% for the group 2 received resveratroloside). The cardioprotective effect of resveratroloside was detected for the first time.
Keywords: Cardiovascular disease, in vivo experiments, ischemia-reperfusion, myocardial infarction, myocardial ischemia, natural stilbenes, Pinus sibirica, preconditioning, resveratrol, resveratroloside.
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title:Cardioprotective Effect of Resveratrol and Resveratroloside
Volume: 11 Issue: 3
Author(s): Sergey E. Naumenko, Tatiana V. Latysheva, Michael A. Gilinsky, Artem D. Rogachev, Nina I. Komarova, Nariman F. Salakhutdinov and Genrikh A. Tolstikov
Affiliation:
Keywords: Cardiovascular disease, in vivo experiments, ischemia-reperfusion, myocardial infarction, myocardial ischemia, natural stilbenes, Pinus sibirica, preconditioning, resveratrol, resveratroloside.
Abstract: Cardioprotective effect of resveratrol and resveratroloside was determined in ischemia-reperfusion experiments on rats. It was found that single intraperitoneal administration of any compound (10 mg/kg) followed by 30-min ischemia and 120-min reperfusion resulted in statistically significant decrease of myocardial infarct area (55.0±4.0% for control group; 40.7±4.4% for the group 1 received resveratrol; 41.6±4.8% for the group 2 received resveratroloside). The cardioprotective effect of resveratroloside was detected for the first time.
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Naumenko E. Sergey, Latysheva V. Tatiana, Gilinsky A. Michael, Rogachev D. Artem, Komarova I. Nina, Salakhutdinov F. Nariman and Tolstikov A. Genrikh, Cardioprotective Effect of Resveratrol and Resveratroloside, Cardiovascular & Hematological Agents in Medicinal Chemistry 2013; 11 (3) . https://dx.doi.org/10.2174/187152571103140120103302
DOI https://dx.doi.org/10.2174/187152571103140120103302 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
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