Abstract
Small non-coding microRNAs (miRNAs) regulate gene expression at the post-transcriptional and translational levels. The dysregulated miRNAs are involved in a large variety of diseases including cancer and cardiovascular diseases. MiR-34a is one of the most anti-oncomiRs that is down-regulated in multiple types of cancer. It regulates a wide range of genes and pathways involved in cancer initiation, progression and metastasis. Next to cancer, miR-34a is recently found to be implicated in cardiovascular disease as one damager factor. In this review, we highlight the complex roles of miR-34a in cancer and cardiovascular disease, as well as the therapeutic potentials.
Keywords: Cardiovascular diseases, microRNA-34a, molecular target therapy, neoplasms.
Current Drug Targets
Title:MicroRNA-34a: Role in Cancer and Cardiovascular Disease
Volume: 15 Issue: 4
Author(s): Xi Chen, Jian-Ya Zhou and Jian-Ying Zhou
Affiliation:
Keywords: Cardiovascular diseases, microRNA-34a, molecular target therapy, neoplasms.
Abstract: Small non-coding microRNAs (miRNAs) regulate gene expression at the post-transcriptional and translational levels. The dysregulated miRNAs are involved in a large variety of diseases including cancer and cardiovascular diseases. MiR-34a is one of the most anti-oncomiRs that is down-regulated in multiple types of cancer. It regulates a wide range of genes and pathways involved in cancer initiation, progression and metastasis. Next to cancer, miR-34a is recently found to be implicated in cardiovascular disease as one damager factor. In this review, we highlight the complex roles of miR-34a in cancer and cardiovascular disease, as well as the therapeutic potentials.
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Cite this article as:
Chen Xi, Zhou Jian-Ya and Zhou Jian-Ying, MicroRNA-34a: Role in Cancer and Cardiovascular Disease, Current Drug Targets 2014; 15 (4) . https://dx.doi.org/10.2174/1389450115666140120102935
DOI https://dx.doi.org/10.2174/1389450115666140120102935 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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