Abstract
Racemic solketal (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol 1, was treated with carboxylic acids of varying chain length or their vinyl esters in the presence of different lipases. The esterification reaction was carried out in n-hexane or diisopropyl ether as a solvent. The yield of the solketal esters and their enantiopurity were satisfactory, as indicated by gas chromatography using chiral column. Lipases from Rhizopus oryzae and Pseudomonas fluorescence gave the best enantiomeric excess (ee) when the solketal was treated with vinyl butyrate in a solution of diisopropyl ether at room temperature.
Keywords: Esterification, solketal, lipases, enantiopurity, biocatalysis.
Letters in Organic Chemistry
Title:Lipases Aided Esterification of (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol
Volume: 11 Issue: 1
Author(s): Aurelia Zniszczol and Krzysztof Z. Walczak
Affiliation:
Keywords: Esterification, solketal, lipases, enantiopurity, biocatalysis.
Abstract: Racemic solketal (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol 1, was treated with carboxylic acids of varying chain length or their vinyl esters in the presence of different lipases. The esterification reaction was carried out in n-hexane or diisopropyl ether as a solvent. The yield of the solketal esters and their enantiopurity were satisfactory, as indicated by gas chromatography using chiral column. Lipases from Rhizopus oryzae and Pseudomonas fluorescence gave the best enantiomeric excess (ee) when the solketal was treated with vinyl butyrate in a solution of diisopropyl ether at room temperature.
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Cite this article as:
Zniszczol Aurelia and Walczak Z. Krzysztof, Lipases Aided Esterification of (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol, Letters in Organic Chemistry 2014; 11 (1) . https://dx.doi.org/10.2174/157017861101140113155507
DOI https://dx.doi.org/10.2174/157017861101140113155507 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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