Abstract
The studies of new anti-cancer drugs are constantly in the centre of scientific interest. This paper provides an overview of the complex compounds of platinum(II) and palladium(II) as anti-cancer drugs. These drugs have been described in dependence on the type of cells which are under the influence of the cytotoxic drug and side effects arising from the use of the drug. In the case of some drugs such as cisplatin or trans-[PtCl2(tz)2] the mechanisms of action in the body are described. Furthermore, in the paper the methods used for cytotoxicity determination of chemical compounds considered to be used as anticancer drugs are described. The MTT, MTS, LDH, BrdU, Alamar Blue and Neutral Red test are examples of such methods.
Keywords: Cisplatin, cytotoxicity, platinum(II) and palladium(II) complexes.
Current Pharmaceutical Analysis
Title:Platinum(II) and Palladium(II) Complex Compounds as Anti-cancer Drugs. Methods of Cytotoxicity Determination
Volume: 10 Issue: 1
Author(s): Joanna Pranczk, Dagmara Jacewicz, Dariusz Wyrzykowski and Lech Chmurzynski
Affiliation:
Keywords: Cisplatin, cytotoxicity, platinum(II) and palladium(II) complexes.
Abstract: The studies of new anti-cancer drugs are constantly in the centre of scientific interest. This paper provides an overview of the complex compounds of platinum(II) and palladium(II) as anti-cancer drugs. These drugs have been described in dependence on the type of cells which are under the influence of the cytotoxic drug and side effects arising from the use of the drug. In the case of some drugs such as cisplatin or trans-[PtCl2(tz)2] the mechanisms of action in the body are described. Furthermore, in the paper the methods used for cytotoxicity determination of chemical compounds considered to be used as anticancer drugs are described. The MTT, MTS, LDH, BrdU, Alamar Blue and Neutral Red test are examples of such methods.
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Pranczk Joanna, Jacewicz Dagmara, Wyrzykowski Dariusz and Chmurzynski Lech, Platinum(II) and Palladium(II) Complex Compounds as Anti-cancer Drugs. Methods of Cytotoxicity Determination, Current Pharmaceutical Analysis 2014; 10 (1) . https://dx.doi.org/10.2174/157341291001140102103324
DOI https://dx.doi.org/10.2174/157341291001140102103324 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
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